肌氨酸合成减少能否预防他汀类药物肌病？
Does reduced creatine synthesis protect against statin myopathy?
机构信息
Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA.
出版信息
Cell Metab. 2013 Dec 3;18(6):773-4. doi: 10.1016/j.cmet.2013.11.012.
Abstract
Statins, widely used to lower cholesterol levels, cause myopathy in some patients. Mangravite et al. (2013) show that a single nucleotide polymorphism decreasing expression of glycine amidinotransferase (GATM), the enzyme regulating creatine biosynthesis, is associated with reduced statin myopathy. Whether reduced creatine production protects against statin myopathy remains to be determined.
摘要
他汀类药物广泛用于降低胆固醇水平，但会导致部分患者出现肌肉疾病。Mangravite 等人（2013 年）表明，降低甘氨酸脒基转移酶（GATM）表达的单核苷酸多态性与他汀类药物引起的肌肉疾病减少有关，GATM 是调节肌酸生物合成的酶。减少肌酸生成是否能预防他汀类药物引起的肌肉疾病仍有待确定。
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本文引用的文献
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Nature. 2013 Oct 17;502(7471):377-80. doi: 10.1038/nature12508. Epub 2013 Aug 28.
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Ann Intern Med. 2010 Nov 16;153(10):690-2. doi: 10.7326/0003-4819-153-10-201011160-00024.
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