Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China.
Clin Chim Acta. 2014 Feb 15;429:163-7. doi: 10.1016/j.cca.2013.11.029. Epub 2013 Dec 4.
We investigated serum lipoprotein(a) complexes with beta2-glycoprotein I [β2-GPI-Lp(a)] levels in ischemic stroke patients.
Serum β2-GPI-Lp(a), oxidized Lp(a) [ox-Lp(a)] and Lp(a) levels were determined in 124 ischemic stroke patients and 64 normal controls. The severity and clinical outcome of ischemic stroke patients were evaluated by the National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI), respectively. The correlation analysis and multiple linear regression analysis were performed.
Compared with controls, serum β2-GPI-Lp(a), ox-Lp(a) and Lp(a) levels were significantly increased in ischemic stroke patients, and their levels were higher in severe stroke than in mild stroke. The β2-GPI-Lp(a) levels were positively related with ox-Lp(a) (r=0.665, P=0.000) and Lp(a) (r=0.195, P=0.035). NIHSS scores were positively correlated with β2-GPI-Lp(a) (r=0.322, P=0.000), while BI was negatively related with β2-GPI-Lp(a) (r=-0.301, P=0.012). Multiple linear regression analyses showed that β2-GPI-Lp(a) (β coefficient=0.338, P=0.010) and ox-Lp(a) (β coefficient=0.265, P=0.043) were found to account for 25.1% of the variation of NIHSS scores, and that only β2-GPI-Lp(a) (β coefficient=-0.351, P=0.005; adjusted R(2)=0.108) was an independent predictor of BI.
Serum β2-GPI-Lp(a) levels were increased in ischemic stroke patients. Elevated β2-GPI-Lp(a) levels were associated with the severity and clinical outcome of ischemic stroke.
我们研究了缺血性脑卒中患者血清脂蛋白(a)复合物与β2-糖蛋白 I [β2-GPI-Lp(a)]水平。
测定 124 例缺血性脑卒中患者和 64 例正常对照者血清β2-GPI-Lp(a)、氧化型 Lp(a) [ox-Lp(a)]和 Lp(a)水平。采用美国国立卫生研究院卒中量表 (NIHSS)和巴氏指数 (BI)分别评估缺血性脑卒中患者的严重程度和临床转归。进行相关性分析和多元线性回归分析。
与对照组相比，缺血性脑卒中患者血清β2-GPI-Lp(a)、ox-Lp(a)和 Lp(a)水平显著升高，且重度脑卒中患者高于轻度脑卒中患者。β2-GPI-Lp(a)水平与 ox-Lp(a)呈正相关(r=0.665，P=0.000)，与 Lp(a)呈正相关(r=0.195，P=0.035)。NIHSS 评分与β2-GPI-Lp(a)呈正相关(r=0.322，P=0.000)，BI 与β2-GPI-Lp(a)呈负相关(r=-0.301，P=0.012)。多元线性回归分析显示，β2-GPI-Lp(a)(β系数=0.338，P=0.010)和 ox-Lp(a)(β系数=0.265，P=0.043)可解释 NIHSS 评分变异的 25.1%，而只有β2-GPI-Lp(a)(β系数=-0.351，P=0.005；调整 R(2)=0.108)是 BI 的独立预测因子。
缺血性脑卒中患者血清β2-GPI-Lp(a)水平升高。升高的β2-GPI-Lp(a)水平与缺血性脑卒中的严重程度和临床转归有关。
