Meillier Andrew, McGee Jean, Kartan Saritha, Baskin Stuart
New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA.
Internal Medicine Residency Program, Department of Medicine, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.
Int J Infect Dis. 2014 Feb;19:93-4. doi: 10.1016/j.ijid.2013.10.014. Epub 2013 Dec 6.
Chronic hepatitis C virus (HCV) infection is a complex, multi-organ disorder, not just limited to the liver. Mixed cryoglobulinemia (MC) type 2 is a common extrahepatic complication, in which immunoglobulin complexes deposit in vascular endothelium. This in turn creates a diffuse inflammatory reaction, leading to a variety of disorders involving multiple systems. We report the rare case of a patient with cryoglobulinemia, cutaneous vasculitis, membroproliferative glomerulonephritis, and B cell lymphoma with a variant t(6;10) translocation in the setting of an untreated, chronic HCV infection. This case highlights the challenge associated with diagnosing and managing such a complex presentation.
慢性丙型肝炎病毒（HCV）感染是一种复杂的多器官疾病，并不局限于肝脏。2型混合性冷球蛋白血症（MC）是一种常见的肝外并发症，其中免疫球蛋白复合物沉积于血管内皮。这进而引发弥漫性炎症反应，导致涉及多个系统的多种病症。我们报告了一例罕见病例，该患者患有冷球蛋白血症、皮肤血管炎、膜增生性肾小球肾炎和B细胞淋巴瘤，在未经治疗的慢性HCV感染背景下存在t(6;10)易位变异。该病例凸显了诊断和处理这种复杂临床表现所面临的挑战。
