Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
Adv Anat Pathol. 2014 Jan;21(1):63-7. doi: 10.1097/PAP.0000000000000001.
SATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator that is involved in osteoblastic differentiation and is also expressed in the glandular epithelial cells of the lower gastrointestinal tract. Recent studies have shown that, because of its relative specificity for osteoblastic differentiation, SATB2 immunostaining could potentially be a useful adjunct for assisting in the differential diagnosis of both benign and malignant osteogenic tumors. In addition, because SATB2 is also a highly sensitive and specific marker for colorectal adenocarcinomas, it could also serve as a complementary marker in the differential diagnosis of a carcinoma of unknown primary origin.
SATB2 是一种核基质相关转录因子和表观遗传调节剂，参与成骨细胞分化，也在上消化道的腺上皮细胞中表达。最近的研究表明，由于 SATB2 免疫染色对成骨细胞分化具有相对特异性，因此 SATB2 免疫染色可能成为辅助鉴别良性和恶性成骨性肿瘤的有用辅助手段。此外，由于 SATB2 也是结直肠腺癌的高度敏感和特异性标志物，因此它也可以作为未知原发灶癌的鉴别诊断的补充标志物。
