Sun Yang, Long Jianhong, Wang Yongjie
Department of Plastics and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Nov;38(11):1141-5. doi: 10.3969/j.issn.1672-7347.2013.11.010.
To explore the relationship between ABCC11 gene single nucleotide polymorphism (SNP) and the incidence of axillary osmidrosis in Chinese Han population.
The genotype of ABCC11 gene SNP at rs17822931 in 40 patients with axillary osmidrosis and 5 normal Han people was detected and analyzed by high resolution melt and gene sequencing.
The detection of the genotype of ABCC11 gene SNP at rs17822931 showed that: 37 of the 40 patients were GA genotype and the other 3 were GG genotype, while the 5 normal subjects were AA genotype.
SNP in ABCC11 is the genetic cause of axillary osmidrosis. GG or GA leads to axillary osmidrosis, while AA allele presents the absence of axillary osmidrosis.
探讨ABCC11基因单核苷酸多态性（SNP）与中国汉族人群腋臭发病率之间的关系。
采用高分辨率熔解曲线分析和基因测序技术，对40例腋臭患者和5名正常汉族人的ABCC11基因rs17822931位点的SNP基因型进行检测和分析。
ABCC11基因rs17822931位点SNP基因型检测结果显示：40例患者中37例为GA基因型，3例为GG基因型，5名正常对照者均为AA基因型。
ABCC11基因SNP是腋臭的遗传病因。GG或GA基因型可导致腋臭，而AA基因型则表现为无腋臭。
