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Lysophosphatidylcholine potentiates BDNF-induced TrkB phosphorylation and downstream signals in cerebellar granule neurons.

作者信息

Arioka Manabu

机构信息

Department of Biotechnology, The University of Tokyo.

出版信息

Biosci Biotechnol Biochem. 2013;77(12):2510-3. doi: 10.1271/bbb.130622. Epub 2013 Dec 7.

DOI:10.1271/bbb.130622
PMID:24317073
Abstract

We found that brain-derived neurotrophic factor (BDNF)-induced phosphorylation of mitogen-activated protein kinase (MAPK) and Akt in cerebellar granule neurons was specifically potentiated by LPC. LPC also augmented the BDNF-induced phosphorylation of TrkB, the receptor for BDNF. In TrkB-transfected CHO-K1 cells, LPC potentiated BDNF-induced MAPK phosphorylation. These results suggest that LPC plays a role in BDNF-TrkB signaling by regulating the activation of TrkB.

摘要

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