阿糖胞苷联合治疗对5-氮杂-2'-脱氧胞苷抗白血病活性的拮抗作用。
Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine.
作者信息
Colombo T, Rossi C, D'Incalci M
出版信息
Cancer Treat Rep. 1986 Dec;70(12):1451-3.
PMID:2431776
Abstract
In this study we show that cytarabine given simultaneously with 5-aza-2'-deoxycytidine (Aza-dC) antagonized Aza-dC activity against L1210 mouse leukemia. This antagonism was seen after a single dose (on Day 3 or Day 5 after tumor implant) and after repeated doses. This observation suggests caution in combining cytarabine with Aza-dC in the treatment of human leukemias.
摘要
在本研究中，我们发现阿糖胞苷与5-氮杂-2'-脱氧胞苷（阿扎胞苷）同时给药时，会拮抗阿扎胞苷对L1210小鼠白血病的活性。这种拮抗作用在单次给药后（肿瘤接种后第3天或第5天）以及重复给药后均可见到。这一观察结果提示，在治疗人类白血病时，将阿糖胞苷与阿扎胞苷联合使用需谨慎。
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