Immunotherapy targeting cytokines in neuropathic pain.
作者信息
Lees Justin G, Duffy Samuel S, Moalem-Taylor Gila
机构信息
Department of Anatomy, School of Medical Sciences, University of New South Wales Sydney, NSW, Australia.
出版信息
Front Pharmacol. 2013 Nov 22;4:142. doi: 10.3389/fphar.2013.00142. eCollection 2013.
Abstract
摘要
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Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve.坐骨神经单侧慢性压迫损伤后，双侧腰骶和颈背根神经节白细胞介素-6 蛋白和 mRNA 水平升高。
J Neuroinflammation. 2013 May 1;10:55. doi: 10.1186/1742-2094-10-55.
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Eur J Pain. 2013 Jul;17(6):844-57. doi: 10.1002/j.1532-2149.2012.00256.x. Epub 2012 Dec 14.
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Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents.白细胞介素-17使关节伤害感受器对机械刺激敏感，并通过啮齿动物神经元中的白细胞介素-17受体导致关节炎疼痛。
Arthritis Rheum. 2012 Dec;64(12):4125-34. doi: 10.1002/art.37695.
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Selectively reducing cytokine/chemokine expressing macrophages in injured nerves impairs the development of neuropathic pain.选择性减少损伤神经中细胞因子/趋化因子表达的巨噬细胞可损害神经病理性疼痛的发展。
Exp Neurol. 2013 Feb;240:205-18. doi: 10.1016/j.expneurol.2012.11.013. Epub 2012 Nov 21.
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