Naveau S, Roulot D, Zourabichvili O, Poitrine A, Poynard T, Chaput J C
Gastroenterol Clin Biol. 1986 Oct;10(10):651-5.
Fourty-five patients, 28 men, 17 women (mean age 73 +/- 18 yrs) with rectal carcinoma underwent palliative endoscopic neodymium YAG laser therapy. Rectal hemorrhage ceased in 89 p. 100 of affected patients after 3 +/- 2 sessions and a normal rectal transit was restored in 80 p. 100 of affected patients after 3 +/- 1 sessions. Total destruction of intraluminal tumor was achieved in 40 p. 100 of patients after 4 +/- 1 sessions. Symptomatic improvement was more frequent in patients in whom total destruction of intraluminal tumor was achieved (p less than 0.01). Stepwise logistic regression selected 2 independent variables capable of predicting tumoral destruction: the kind of surgical contraindication, more often related to cancer extension (p less than 0.001) and a greater tumor length (p less than 0.03) in patients in whom destruction of intraluminal tumor was incomplete. Twenty-eight patients were subsequently treated after palliation was achieved. Cumulative probability of remaining improved at 6 months when treatment was not stopped was 40 p. 100 (confidence limits to 95 p. 100: 23 p. 100-59 p. 100). Five complications occurred, 3 rectovaginal fistulas and 2 stenosis.
45例直肠癌患者（28例男性，17例女性，平均年龄73±18岁）接受了姑息性内镜钕钇铝石榴石激光治疗。3±2次治疗后，89%的患侧患者直肠出血停止；3±1次治疗后，80%的患侧患者直肠转运恢复正常。4±1次治疗后，40%的患者腔内肿瘤完全被破坏。腔内肿瘤完全被破坏的患者症状改善更为频繁（p<0.01）。逐步逻辑回归分析选择了2个能够预测肿瘤破坏的独立变量：手术禁忌的类型，更常与癌症扩散有关（p<0.001），以及腔内肿瘤破坏不完全的患者中肿瘤长度更长（p<0.03）。28例患者在达到姑息治疗后随后接受了治疗。当治疗未停止时，6个月时仍保持改善的累积概率为40%（95%置信区间：23%-59%）。发生了5例并发症，3例直肠阴道瘘和2例狭窄。
