持续的 4-1BB 共刺激信号对于过继性 T 细胞治疗中肿瘤浸润淋巴细胞的最佳扩增是必需的。
Continuous 4-1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy.
机构信息
Department of Melanoma Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA ; The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
出版信息
Oncoimmunology. 2013 Sep 1;2(9):e25581. doi: 10.4161/onci.25581. Epub 2013 Jul 3.
Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4-1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4-1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions.
肿瘤坏死因子受体 (TNFR) 家族成员的共刺激似乎对于产生具有最佳效应记忆特性的 T 细胞用于过继细胞治疗至关重要。我们的工作表明，持续的 4-1BB/CD137 共刺激对于扩增具有最佳治疗谱的 T 细胞是必需的，并且在过继细胞转移时给予 4-1BB 激动剂进一步改善了抗肿瘤 T 细胞功能。
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