西万格列净和阿托格列净对大鼠肝脏中3-羟基-3-甲基戊二酰辅酶A还原酶表达的影响。
Effects of simvaglyzin and atorvaglyzin on the expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase in rat liver.
作者信息
Stakhneva E M, Vavilin V A, Ragino Yu I, Safronova O G, Shintyapina A B, Ivanova M V
机构信息
Research Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
出版信息
Bull Exp Biol Med. 2013 Nov;156(1):63-5. doi: 10.1007/s10517-013-2278-y.
Activity and levels of protein and mRNA of 3-hydroxy-3-methyl-glutaryl-CoA reductase were estimated in rat liver after the administration of atorvastatin and simvastatin and their complexes with glycyrrhizic acid (atorvaglyzin and simvaglyzin). The amount of 3-hydroxy-3-methyl-glutaryl-CoA reductase protein in rats decreased by 13 and 25% (p<0.05) 24 h after treatment with atorvaglyzin and simvaglyzin, respectively. Activity of this enzyme decreased by 46% in rats treated with atorvaglyzin. The amount of messenger RNA in these groups significantly increased as compared to control group (untreated animals).
在给予大鼠阿托伐他汀、辛伐他汀及其与甘草酸的复合物（阿托伐甘草锌和辛伐甘草锌）后，对大鼠肝脏中3-羟基-3-甲基戊二酰辅酶A还原酶的活性、蛋白质和mRNA水平进行了评估。用阿托伐甘草锌和辛伐甘草锌治疗24小时后，大鼠体内3-羟基-3-甲基戊二酰辅酶A还原酶蛋白的量分别减少了13%和25%（p<0.05）。用阿托伐甘草锌治疗的大鼠中，这种酶的活性降低了46%。与对照组（未治疗的动物）相比，这些组中的信使RNA量显著增加。
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