维司他汀给药后，Wistar大鼠与具有僵住症遗传易感性大鼠淋巴细胞的比较表型及细胞化学特征

Comparative phenotypic and cytochemical characteristics of lymphocytes of Wistar rats and rats with genetic predisposition to catalepsy after retabolil administration.

作者信息

Panteleeva N G, Shurlygina A V, Trufakin V A

机构信息

Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences; Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2013 Nov;156(1):78-80. doi: 10.1007/s10517-013-2282-2.

DOI:10.1007/s10517-013-2282-2

PMID:24319735

Abstract

We studied the possibility of using anabolic steroid retabolil injections for complex correction of behavioral and immune parameters in rats with genetic predisposition to catalepsy. Subpopulation composition of lymphoid organ and blood cells was compared in rats with genetic predisposition to catalepsy and Wistar rats after retabolil administration. In rats predisposed to catalepsy, retabolil reduced the total content of thymus cells and increased absolute count of CD8 (+) thymocytes. In Wistar rats, retabolil increased the total cell count and the content of CD4 (+) thymocytes, but reduced the number of CD8 (+) cells. Therefore, changes in the subpopulation composition of thymus cells after retabolil administration were opposite in rats with genetic predisposition to catalepsy and Wistar rats. Retabolil injections reduced the severity of catalepsy response in rats with genetic predisposition. However, the time of freezing in Wistar rats significantly increased under these conditions.

摘要

我们研究了使用合成代谢类固醇 Retabolil 注射剂对具有遗传性僵住症倾向的大鼠的行为和免疫参数进行综合校正的可能性。比较了在给予 Retabolil 后，具有遗传性僵住症倾向的大鼠和 Wistar 大鼠的淋巴器官和血细胞的亚群组成。在具有遗传性僵住症倾向的大鼠中，Retabolil 降低了胸腺细胞的总数，并增加了 CD8(+)胸腺细胞的绝对计数。在 Wistar 大鼠中，Retabolil 增加了细胞总数和 CD4(+)胸腺细胞的含量，但减少了 CD8(+)细胞的数量。因此，给予 Retabolil 后，具有遗传性僵住症倾向的大鼠和 Wistar 大鼠胸腺细胞亚群组成的变化是相反的。Retabolil 注射降低了具有遗传性僵住症倾向的大鼠的僵住症反应的严重程度。然而，在这些条件下，Wistar 大鼠的僵住时间显著增加。