Nepomnyashchikh G I, Bakarev M A, Nepomnyashchikh D L, Yudanov A V, Kapustina V I, Migus'kova E I, Postnikova O A, Vinogradova E V, Nokhrina Zh V, Savchenko S A
Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2013 Dec;156(2):281-4. doi: 10.1007/s10517-013-2330-y.
Immunohistochemical and PCR analysis of the structure of lipid-containing hepatocytes and replication of chronic hepatitis C viral particles revealed no positive correlation between the presence of HCV RNA in blood specimens, number of infected hepatocytes (by expression of HCV NS3Ag) with clinical biochemical parameters and intensity of structural changes in biopsy specimens. Small-vesicular subcytolemmal lipid infiltration of hepatocytes was detected, presumably associated with hepatitis C virus replication phase. Characteristic subcytolemmal location of the lipid droplets can reflect their involvement in virus transport from the cell and indicate a virus-induced nature of lipid metabolism disorders.
对含脂肝细胞结构及慢性丙型肝炎病毒颗粒复制进行免疫组织化学和聚合酶链反应分析发现，血液标本中丙型肝炎病毒核糖核酸（HCV RNA）的存在、受感染肝细胞数量（通过HCV NS3Ag表达）与临床生化参数以及活检标本结构变化强度之间无正相关关系。检测到肝细胞存在小泡状细胞膜下脂质浸润，推测与丙型肝炎病毒复制阶段有关。脂滴在细胞膜下的特征性定位可反映它们参与病毒从细胞的转运，并表明脂质代谢紊乱具有病毒诱导的性质。
