Zhilyakova E T, Novikov O O, Akopova V V
Belgorod State National Research University, Belgorod, Russia.
Bull Exp Biol Med. 2013 Dec;156(2):290-4. doi: 10.1007/s10517-013-2332-9.
The time course of drug adsorption and desorption, exposure of soft contact lenses in a drug solution needed for maximum saturation, and the duration of lens wearing during which the drug was transported from the lens and exhibited its therapeutic activity were studied. The possibility of using computer simulation for the choice of material, carrier for the drug (myramistin hydrochloride), was evaluated. Due to use of this method, the volume of experimental studies could be reduced and the data systematized.
研究了药物吸附和解吸的时间进程、软性隐形眼镜在达到最大饱和度所需的药物溶液中的暴露情况，以及药物从镜片转运并发挥其治疗活性的镜片佩戴持续时间。评估了使用计算机模拟来选择药物（盐酸米拉美斯汀）的材料、载体的可能性。由于使用了这种方法，可以减少实验研究的量并使数据系统化。
