53BP1 在调控 DNA 双链断裂修复途径选择中的作用。
Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice.
机构信息
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
出版信息
Radiat Res. 2014 Jan;181(1):1-8. doi: 10.1667/RR13572.1. Epub 2013 Dec 9.
Abstract
The p53-binding protein 1 (53BP1) is a well-known DNA damage response (DDR) factor, which is recruited to nuclear structures at the site of DNA damage and forms readily visualized ionizing radiation (IR) induced foci. Depletion of 53BP1 results in cell cycle arrest in G2/M phase as well as genomic instability in human as well as mouse cells. Within the DNA damage response mechanism, 53BP1 is classified as an adaptor/mediator, required for processing of the DNA damage response signal and as a platform for recruitment of other repair factors. More recently, specific 53BP1 contributions to DSB repair pathway choice have been recognized and are being characterized. In this review, we have summarized recent advances in understanding the role of 53BP1 in regulating DNA DSBs repair pathway choice, variable diversity joining [V(D)J] recombination and class-switch recombination (CSR).
摘要
p53 结合蛋白 1（53BP1）是一种众所周知的 DNA 损伤反应（DDR）因子，它可被招募到 DNA 损伤部位的核结构中，并形成易于观察的电离辐射（IR）诱导焦点。53BP1 的耗竭会导致人类和小鼠细胞的 G2/M 期细胞周期停滞以及基因组不稳定性。在 DNA 损伤反应机制中，53BP1 被归类为一种衔接子/中介物，需要对 DNA 损伤反应信号进行处理，并作为招募其他修复因子的平台。最近，人们已经认识到 53BP1 对 DSB 修复途径选择的特定贡献，并正在对其进行表征。在这篇综述中，我们总结了对 53BP1 在调节 DNA DSBs 修复途径选择、可变多样性连接[V(D)J]重组和类别转换重组（CSR）中的作用的最新理解进展。
相似文献
1
Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice.53BP1 在调控 DNA 双链断裂修复途径选择中的作用。
Radiat Res. 2014 Jan;181(1):1-8. doi: 10.1667/RR13572.1. Epub 2013 Dec 9.
2
Two- and three-dimensional live cell imaging of DNA damage response proteins.DNA损伤反应蛋白的二维和三维活细胞成像
J Vis Exp. 2012 Sep 28(67):4251. doi: 10.3791/4251.
3
53BP1-mediated DNA double strand break repair: insert bad pun here.53BP1 介导的 DNA 双链断裂修复：插入一个蹩脚的双关语。
DNA Repair (Amst). 2011 Oct 10;10(10):1071-6. doi: 10.1016/j.dnarep.2011.07.012. Epub 2011 Aug 24.
4
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.异染色质对 DNA 双链断裂修复的影响：让沉默的强势者放松。
DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30.
5
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks.53BP1 在修复辐射诱导的 DNA 双链断裂中的作用。
DNA Repair (Amst). 2020 Sep;93:102915. doi: 10.1016/j.dnarep.2020.102915.
6
Double-strand break repair: 53BP1 comes into focus.双链断裂修复：53BP1 成为焦点。
Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
7
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.53BP1 依赖性的稳定的局部 KAP-1 磷酸化对于异染色质 DNA 双链断裂修复是必需的。
Nat Cell Biol. 2010 Feb;12(2):177-84. doi: 10.1038/ncb2017. Epub 2010 Jan 17.
8
PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.PAXX和XLF DNA修复因子在连接处于G1期停滞的祖B细胞系中的DNA断裂方面功能冗余。
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10619-24. doi: 10.1073/pnas.1611882113. Epub 2016 Sep 6.
9
Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair.DNA-PK 复合物和 53BP1 在 DNA 双链断裂修复过程中保护末端免受切除的作用。
J Radiat Res. 2020 Sep 8;61(5):718-726. doi: 10.1093/jrr/rraa053.
10
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.53BP1在V(D)J重组过程中促进远距离DNA末端连接。
Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.
引用本文的文献
1
Short and long-term effects on the thyroid proteome after 131I exposure.131I 暴露后对甲状腺蛋白质组的短期和长期影响。
Radiat Prot Dosimetry. 2025 Aug 26;201(13-14):919-933. doi: 10.1093/rpd/ncaf073.
2
Crosstalk between DNA damage and cGAS-STING immune pathway drives neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease.DNA损伤与cGAS-STING免疫通路之间的串扰驱动帕金森病中的神经炎症和多巴胺能神经变性。
Brain Behav Immun. 2025 Jul 31:106065. doi: 10.1016/j.bbi.2025.106065.
3
Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency.DNA损伤反应受损和炎症信号传导是Gata2单倍体不足时造血干细胞缺陷的基础。
Stem Cell Reports. 2025 Aug 12;20(8):102596. doi: 10.1016/j.stemcr.2025.102596. Epub 2025 Jul 31.
4
The Redox Activity of Protein Disulphide Isomerase Functions in Non-Homologous End-Joining Repair to Prevent DNA Damage.蛋白质二硫键异构酶的氧化还原活性在非同源末端连接修复中发挥作用以防止DNA损伤。
Aging Cell. 2025 Jul;24(7):e70079. doi: 10.1111/acel.70079. Epub 2025 May 15.
5
LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers.LC8通过53BP1寡聚体的异质桥接增强53BP1病灶。
Elife. 2025 Apr 29;14. doi: 10.7554/eLife.102179.
6
Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma.α-突触核蛋白调节黑色素瘤中的核仁DNA双链断裂修复。
Sci Adv. 2025 Apr 11;11(15):eadq2519. doi: 10.1126/sciadv.adq2519. Epub 2025 Apr 9.
7
Aurora Kinase A and B inhibition abrogates 'Neosis', a non-mitotic cell division of GBM residual cells and prevents GBM recurrence.极光激酶A和B的抑制作用可消除“新细胞生成”（一种胶质母细胞瘤残留细胞的非有丝分裂细胞分裂），并预防胶质母细胞瘤复发。
Oncogene. 2025 Apr 7. doi: 10.1038/s41388-025-03372-6.
8
Dynamic interactions of dimeric hub proteins underlie their diverse functions and structures: A comparative analysis of 14-3-3 and LC8.二聚体枢纽蛋白的动态相互作用构成其多样的功能和结构：14-3-3与LC8的比较分析
J Biol Chem. 2025 Apr;301(4):108416. doi: 10.1016/j.jbc.2025.108416. Epub 2025 Mar 17.
9
root extract exerts anti-TNBC potential by regulating FAK-related signalling pathways.根提取物通过调节与粘着斑激酶（FAK）相关的信号通路发挥抗三阴性乳腺癌（TNBC）的潜力。
Am J Cancer Res. 2024 Sep 15;14(9):4265-4285. doi: 10.62347/MYPG4066. eCollection 2024.
10
A single dose of radiation elicits comparable acute salivary gland injury to fractionated radiation.单次剂量的辐射引发的急性唾液腺损伤与分次辐射相当。
Dis Model Mech. 2024 Aug 1;17(8). doi: 10.1242/dmm.050733. Epub 2024 Aug 22.
本文引用的文献
1
The logic and mechanism of homologous recombination partner choice.同源重组伙伴选择的逻辑和机制。
Mol Cell. 2013 Aug 22;51(4):440-53. doi: 10.1016/j.molcel.2013.08.008.
2
Opposing roles for 53BP1 during homologous recombination.53BP1 在同源重组中的相反作用。
Nucleic Acids Res. 2013 Nov;41(21):9719-31. doi: 10.1093/nar/gkt729. Epub 2013 Aug 22.
3
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.53BP1 是 DNA 损伤诱导的 H2A 赖氨酸 15 泛素标记的读取器。
Nature. 2013 Jul 4;499(7456):50-4. doi: 10.1038/nature12318. Epub 2013 Jun 12.
4
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.53BP1 通过不同的磷酸化蛋白相互作用介导有性和诱变 DNA 修复。
Cell. 2013 Jun 6;153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.
5
RIF1 counteracts BRCA1-mediated end resection during DNA repair.RIF1 拮抗 BRCA1 介导的 DNA 修复过程中的末端切除。
J Biol Chem. 2013 Apr 19;288(16):11135-43. doi: 10.1074/jbc.M113.457440. Epub 2013 Mar 13.
6
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.乙酰化限制 53BP1 与受损染色质的结合，以促进同源重组。
Nat Struct Mol Biol. 2013 Mar;20(3):317-25. doi: 10.1038/nsmb.2499. Epub 2013 Feb 3.
7
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.暴露于电离辐射后组蛋白修饰和 DNA 双链断裂修复。
Radiat Res. 2013 Apr;179(4):383-92. doi: 10.1667/RR3308.2. Epub 2013 Feb 1.
8
Chromatin modifications and the DNA damage response to ionizing radiation.染色质修饰与电离辐射的 DNA 损伤反应。
Front Oncol. 2013 Jan 22;2:214. doi: 10.3389/fonc.2012.00214. eCollection 2012.
9
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.一个由 53BP1-RIF1 和 BRCA1-CtIP 组成的细胞周期依赖性调控回路控制 DNA 修复途径的选择。
Mol Cell. 2013 Mar 7;49(5):872-83. doi: 10.1016/j.molcel.2013.01.001. Epub 2013 Jan 17.
10
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.RIF1 对于 53BP1 依赖性非同源末端连接和抑制 DNA 双链断裂切除是必需的。
Mol Cell. 2013 Mar 7;49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17.
Zotero 插件