Brewer Jerry D, Habermann Thomas M, Shanafelt Tait D
Division of Dermatologic Surgery, Mayo Clinic, Rochester, MN, USA.
Int J Dermatol. 2014 Mar;53(3):267-74. doi: 10.1111/ijd.12208. Epub 2013 Dec 10.
The link between immunosuppression and skin cancer has been well described. The two most common situations involving immunosuppression-associated skin cancer are solid organ transplantation and non-Hodgkin lymphoma (NHL), including chronic lymphocytic leukemia (CLL). Patients with lymphoma are more likely to have development of a secondary malignancy, with skin cancer being the most common. The most common types of skin cancer in patients with NHL/CLL include melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Many skin cancers demonstrate increased aggressiveness in patients with NHL/CLL and are associated with higher recurrence rates, increased regional metastasis, and death secondary to skin cancer metastases. This review delineates the current research regarding the relationship between NHL/CLL and cutaneous malignancy. Immunosuppressed patients with skin cancer should be treated promptly and aggressively to decrease recurrence and metastases. Regular skin self-examinations, dermatologic examinations, sun-protective habits, and education may prove beneficial in this high-risk patient population.
免疫抑制与皮肤癌之间的联系已得到充分描述。涉及免疫抑制相关皮肤癌的两种最常见情况是实体器官移植和非霍奇金淋巴瘤（NHL），包括慢性淋巴细胞白血病（CLL）。淋巴瘤患者更有可能发生继发性恶性肿瘤，其中皮肤癌最为常见。NHL/CLL患者中最常见的皮肤癌类型包括黑色素瘤、鳞状细胞癌、基底细胞癌和默克尔细胞癌。许多皮肤癌在NHL/CLL患者中表现出更强的侵袭性，并且与更高的复发率、区域转移增加以及皮肤癌转移导致的死亡相关。本综述阐述了目前关于NHL/CLL与皮肤恶性肿瘤之间关系的研究。患有皮肤癌的免疫抑制患者应及时且积极地接受治疗，以降低复发和转移风险。定期进行皮肤自我检查、皮肤科检查、防晒习惯及相关教育可能对这一高危患者群体有益。
