Katayama Y, Tsubokawa T, Hirayama T, Kido G, Tsukiyama T, Iio M
J Cereb Blood Flow Metab. 1986 Dec;6(6):637-41. doi: 10.1038/jcbfm.1986.118.
To clarify functional neural pathways originating from the thalamic nucleus ventralis posterolateralis (VPL) in humans, the responses of regional CBF (rCBF) and regional CMRO2 (rCMRO2) to VPL stimulation were investigated by positron emission tomography in five patients who had undergone chronic implantation of electrodes into the VPL for therapeutic purposes. Measurement of rCBF and rCMRO2 under continuous inhalation of C15O2 and 15O2 by steady-state methods revealed significant increases of rCBF and rCMRO2 in the frontal, postcentral, and thalamic regions. The increases in rCBF and rCMRO2 of the postcentral regions were clearly predominant in the stimulated hemisphere insofar as the stimulation produced moderate paresthesia in restricted areas of the body. These results indicate that the VPL relays peripheral somatosensory information, which has previously been demonstrated to be transmitted to the frontal as well as postcentral regions.
为了阐明人类丘脑腹后外侧核（VPL）发出的功能性神经通路，我们通过正电子发射断层扫描技术，对5名因治疗目的而长期将电极植入VPL的患者，研究了区域脑血流量（rCBF）和区域脑氧代谢率（rCMRO2）对VPL刺激的反应。通过稳态方法在持续吸入C15O2和15O2的情况下测量rCBF和rCMRO2，结果显示额叶、中央后回和丘脑区域的rCBF和rCMRO2显著增加。只要刺激在身体的受限区域产生中度感觉异常，中央后回区域的rCBF和rCMRO2增加在受刺激半球中就明显占主导地位。这些结果表明，VPL传递外周躯体感觉信息，此前已证明该信息会传递到额叶以及中央后回区域。
