对乙酰氨基酚与哮喘的关系：上呼吸道能带来什么启示？
The association between acetaminophen and asthma: is there anything to learn from the upper airways?
机构信息
aDivision of Allergy and Clinical Immunology bDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2014 Feb;14(1):25-8. doi: 10.1097/ACI.0000000000000026.
PURPOSE OF REVIEW
To examine the literature evidence for the association between acetaminophen (paracetamol) use and development of rhinitis.
RECENT FINDINGS
Increased use of acetaminophen (paracetamol) as the favored antipyretic during pregnancy and infancy has been hypothesized to be a risk factor for the development of asthma. There is a paucity of well designed birth cohort studies to examine paracetamol as a risk factor in the development of rhinitis. Confounding by antibiotic use, viral infections, and recall bias are problematic for many of the studies that are published.
SUMMARY
Prospective birth cohorts need to dedicate sufficient time and research personnel to adequately assess paracetamol exposure as a primary variable of interest rather than as an incidental exposure variable collected during routine questionnaire administration.
目的综述
考察有关扑热息痛（对乙酰氨基酚）使用与鼻炎发展之间关联的文献证据。
最近的发现
人们推测，在怀孕期间和婴儿期增加使用扑热息痛（对乙酰氨基酚）作为首选退烧药是哮喘发展的一个风险因素。缺乏精心设计的出生队列研究来检查扑热息痛是否是鼻炎发展的一个风险因素。对于许多已发表的研究，抗生素使用、病毒感染和回忆偏倚的混杂是个问题。
总结
前瞻性出生队列需要投入足够的时间和研究人员，以充分评估扑热息痛暴露作为主要关注的变量，而不是作为常规问卷调查过程中偶然收集的暴露变量。
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