Mărginean Cristina Oana, Cotoi O S, Pitea Ana Maria, Mocanu Simona, Mărginean Cl
Department of Cell and Molecular Biology, University of Medicine and Pharmacy of Tirgu Mures, Romania;
Rom J Morphol Embryol. 2013;54(3 Suppl):709-15.
Helicobacter pylori infection is an important cause of gastritis in childhood, its role in the pathogenesis of peptic ulcer disease in adults and children being generally known. In some cases, there are therapeutic management issues, because they do not heal or they often relapse, although treatment regimens are applied as recommended. Our aim was to analyze the relationship between endoscopic appearance and histological changes of the gastric mucosa in children with gastritis associated with H. pylori infection, in which persistent infection after treatment was found.
It was a prospective study on 1332 children assessed in our Service (Ist Pediatric Clinic, Tirgu Mures, Romania), between January 2008 and January 2013, for gastritis with various etiologies. There were 609 cases of gastritis-associated with H. pylori infection.
The average age of patients was 13.21 years; the higher incidence was noted in 13-18-year-old group, female gender and rural areas provenience; a number of 544 patients diagnosed with gastritis with H. pylori were reassessed subsequently; after treatment, gastritis has healed and the infection was eradicated in 88.23% cases after a month, while in 64 patients infection persisted. After a second regimen, endoscopic-histological modifications persisted in 31 (5.69%) cases; 1.28% cases remained positive for longer.
H. pylori infection was associated with high age group, as well as with endoscopic modifications; also, the presence of H. pylori was correlated with histopathologic diagnostic. We try to emphasize the importance of assessing bacterial resistance to antibiotics, studying of bacterial genome and genetic susceptibility of human subjects.
幽门螺杆菌感染是儿童胃炎的重要病因，其在成人和儿童消化性溃疡疾病发病机制中的作用已广为人知。在某些情况下，存在治疗管理问题，因为尽管按照推荐应用了治疗方案，但溃疡仍未愈合或经常复发。我们的目的是分析幽门螺杆菌感染相关胃炎患儿胃黏膜内镜表现与组织学变化之间的关系，这些患儿在治疗后发现存在持续感染。
这是一项对2008年1月至2013年1月期间在我们科室（罗马尼亚特尔古穆列什第一儿科诊所）评估的1332例因各种病因患胃炎的儿童进行的前瞻性研究。其中有609例与幽门螺杆菌感染相关的胃炎病例。
患者的平均年龄为13.21岁；13 - 18岁组、女性及农村地区来源的发病率较高；随后对544例诊断为幽门螺杆菌相关性胃炎的患者进行了重新评估；治疗后，1个月后88.23%的病例胃炎已愈合且感染被根除，而64例患者感染持续存在。在第二个治疗方案后，31例（5.69%）病例内镜 - 组织学改变持续存在；1.28%的病例长期保持阳性。
幽门螺杆菌感染与高龄组以及内镜改变相关；此外，幽门螺杆菌的存在与组织病理学诊断相关。我们试图强调评估细菌对抗生素的耐药性、研究细菌基因组和人类遗传易感性的重要性。
