Lozinsky Adriana Chebar, Boé Cristiane, Palmero Ricardo, Fagundes-Neto Ulysses
Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Pediatria, SP, Brasil.
Arq Gastroenterol. 2013 Jul-Sep;50(3):226-30. doi: 10.1590/S0004-28032013000200040.
Fructose is a monosaccharide frequently present in natural and artificial juice fruits. When the concentration of fructose in certain food is present in excess of glucose concentration some individuals may develop fructose malabsorption.
To report the frequency of fructose malabsorption utilizing the hydrogen breath test in children with gastrointestinal and/or nutritional disorders.
Between July 2011 and July 2012, 43 patients with gastrointestinal and/or nutritional disorders, from both sexes, were consecutively studied, utilizing the hydrogen breath test with loads of the following carbohydrates: lactose, glucose, fructose and lactulose. Fructose was offered in a 10% aqueous solution in the dose of 1 g/kg body weight. Samples were collected fasting and at every 15 minutes after the intake of the aqueous solution for a 2 hour period. Malabsorption was considered when there was an increase of >20 ppm of hydrogen over the fasting level, and intolerance was diagnosed if gastrointestinal symptoms would appear.
The age of the patients varied from 3 months to 16 years, 24 were boys. The following diagnosis were established: irritable bowel syndrome with diarrhea in 16, functional abdominal pain in 8, short stature in 10, lactose intolerance in 3, celiac disease in 1, food allergy in 1 and giardiasis in 1 patient. Fructose malabsorption was characterized in 13 (30.2%) patients, and intolerance in 1 (2.3%) patient. The most frequent fructose malabsorption was characterized in 7 (16.3%) patients with irritable bowel syndrome and in 4 (9.3%) patients with functional abdominal pain.
Patients with irritable bowel syndrome and functional abdominal pain were the main cause of fructose malabsorption.
果糖是一种常见于天然和人工果汁水果中的单糖。当某些食物中的果糖浓度超过葡萄糖浓度时，一些个体可能会出现果糖吸收不良。
利用氢呼气试验报告患有胃肠道和/或营养障碍儿童中果糖吸收不良的发生率。
在2011年7月至2012年7月期间，对43例患有胃肠道和/或营养障碍的患者（男女均有）进行了连续研究，采用氢呼气试验，给予以下碳水化合物负荷：乳糖、葡萄糖、果糖和乳果糖。果糖以10%的水溶液形式提供，剂量为1 g/kg体重。在空腹时以及摄入水溶液后的2小时内每隔15分钟采集样本。当氢气含量比空腹水平增加>20 ppm时，考虑为吸收不良；如果出现胃肠道症状，则诊断为不耐受。
患者年龄从3个月至16岁不等，其中24例为男孩。确诊的疾病如下：腹泻型肠易激综合征16例、功能性腹痛8例、身材矮小10例、乳糖不耐受3例、乳糜泻1例、食物过敏1例、贾第虫病1例。13例（30.2%）患者表现为果糖吸收不良，1例（2.）患者表现为不耐受。最常见的果糖吸收不良表现为7例（16.3%）腹泻型肠易激综合征患者和4例（9.3%）功能性腹痛患者。
肠易激综合征和功能性腹痛患者是果糖吸收不良的主要原因。
