侧流吸烟对大鼠随意型皮瓣存活的影响。

Effect of side-stream smoking on random-pattern skin flap survival in rats.

作者信息

Gazzalle Anajara, Teixeira Lourenço Frigeri, Pellizzari Alice Cardoso, Cocolichio Fernanda, Zampieri Juliana Tonietto, Rauber Daniel, Pezzin Luíse S, Zago Vanessa D, Braga-Silva Jefferson Luis

机构信息

From the *Division of Hand Surgery and Reconstructive Microsurgery, Hospital São Lucas, and †School of Medicine at the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.

出版信息

Ann Plast Surg. 2014 Apr;72(4):463-6. doi: 10.1097/SAP.0b013e318262395c.

DOI:10.1097/SAP.0b013e318262395c

PMID:24322641

Abstract

The secondhand exposure to cigarette smoke is being considered evil, and damage caused by this passive exposure has been proven by several studies. To investigate the effects of sidestream smoke exposure on random-pattern skin flap survival, 20 female rats were separated into 2 groups: group A (n = 10) was exposed 6 weeks to the smoke from the burning cigarette (passive smoking) and group B (n = 10) was the control group. After 6 weeks of exposition, a dorsal McFarlane flap of 4 × 10 cm was performed in all rats. Two weeks after this procedure, the ratio of necrotic and total areas was calculated using computer programs. The median area of necrosis in group A was 29.5%, significantly higher than that in group B with 17.5% (P < 0.024). In conclusion, this study suggests increased risk of random-pattern skin flap necrosis after sidestream exposure to cigarette smoke.

摘要

二手烟暴露被视为有害，多项研究已证实这种被动暴露所造成的损害。为研究侧流烟雾暴露对随意型皮瓣存活的影响，将20只雌性大鼠分为两组：A组（n = 10）暴露于燃烧香烟的烟雾中6周（被动吸烟），B组（n = 10）为对照组。暴露6周后，对所有大鼠进行4×10 cm的背部麦克法兰皮瓣手术。该手术后两周，使用计算机程序计算坏死面积与总面积的比例。A组坏死面积的中位数为29.5%，显著高于B组的17.5%（P < 0.024）。总之，本研究表明侧流暴露于香烟烟雾后，随意型皮瓣坏死风险增加。