Department of Radiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.
Hepatobiliary Pancreat Dis Int. 2013 Dec;12(6):617-21. doi: 10.1016/s1499-3872(13)60097-1.
Assessment of tumor response after argon-helium cryoablation is critical in guiding future therapy for unresectable hepatocellular carcinoma. This study aimed to evaluate liver hemodynamics in hepatocellular carcinoma after argon-helium cryoablation with computed tomography perfusion.
The control group comprised 40 volunteers without liver disease. The experimental group was composed of 15 patients with hepatocellular carcinoma treated with argon-helium cryoablation. Computed tomography perfusion parameters were measured: hepatic blood flow, hepatic blood volume, mean transit time, permeability of capillary vessel surface, hepatic arterial fraction, hepatic arterial perfusion, and hepatic portal perfusion.
After treatment, in the tumor foci, permeability of capillary vessel surface was higher, and hepatic blood flow, hepatic blood volume, hepatic arterial fraction, and hepatic arterial perfusion values were lower (P<0.05). In the liver parenchyma surrounding the tumor, hepatic arterial perfusion was significantly lower (P<0.05); however, there was no significant difference in hepatic blood flow, hepatic blood volume, mean transit time, permeability of capillary vessel surface, hepatic arterial fraction, or hepatic portal perfusion (P>0.05).
Computed tomography perfusion can evaluate tumor response after argon-helium cryoablation.
评估氩氦冷冻消融后肿瘤的反应对于指导不可切除的肝细胞癌的未来治疗至关重要。本研究旨在使用 CT 灌注评估氩氦冷冻消融后肝癌的肝血流动力学。
对照组由 40 名无肝病的志愿者组成。实验组由 15 名接受氩氦冷冻消融治疗的肝癌患者组成。测量 CT 灌注参数：肝血流量、肝血容量、平均通过时间、毛细血管表面通透性、肝动脉分数、肝动脉灌注和肝门静脉灌注。
治疗后，肿瘤灶内毛细血管表面通透性升高，肝血流量、肝血容量、肝动脉分数和肝动脉灌注值降低（P<0.05）。肿瘤周围肝实质内肝动脉灌注明显降低（P<0.05）；但肝血流量、肝血容量、平均通过时间、毛细血管表面通透性、肝动脉分数或肝门静脉灌注无显著差异（P>0.05）。
CT 灌注可评估氩氦冷冻消融后的肿瘤反应。
