Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:356-64. doi: 10.1016/j.saa.2013.11.065. Epub 2013 Nov 21.
Six organotin(IV) carboxylates of the type R2SnL2 [R=CH3 (1), n-C4H9 (2), n-C8H17 (3)] and R3SnL [R=CH3 (4), n-C4H9 (5), C6H5 (6), where L=2-(4-ethoxybenzylidene) butanoic acid, have been synthesized and characterized by elemental analysis, FT-IR and NMR ((1)H, (13)C). The complex (1) was also analyzed by single crystal X-ray analysis. The complexes were screened for antimicrobial, cytotoxic and anti-tumor activities. The results showed significant activity in each area of the activity with few exceptions. DNA interactions studies of ligand HL and representative complex 2 were investigated by UV-Visible absorption spectroscopy and viscosity measurements. The results showed that both ligand HL and complex 2 interact with SS-DNA via intercalation as well as minor groove binding.
六种有机锡（IV）羧酸酯 R2SnL2 [R=CH3（1），n-C4H9（2），n-C8H17（3）]和 R3SnL [R=CH3（4），n-C4H9（5），C6H5（6），其中 L=2-（4-乙氧基亚苄基）丁酰酸]已被合成并通过元素分析、FT-IR 和 NMR（（1）H、（13）C）进行了表征。复合物（1）还通过单晶 X 射线分析进行了分析。这些配合物被筛选用于抗菌、细胞毒性和抗肿瘤活性。结果表明，除了少数例外，在每个活性区域都具有显著的活性。通过紫外可见吸收光谱和粘度测量研究了配体 HL 和代表性配合物 2 与 DNA 的相互作用。结果表明，配体 HL 和配合物 2 均通过嵌入以及小沟结合与 SS-DNA 相互作用。
