Zheng Jia-He, Chang Zhi-Hui, Han Cheng-Bo, Ma Jie-Tao, Liu Zhao-Yu, Lu Zai-Ming, Guo Qi-Yong
Departments of aRadiology bOncology, Shengjing Hospital of China Medical University, Shenyang, China.
Nucl Med Commun. 2014 Apr;35(4):339-46. doi: 10.1097/MNM.0000000000000057.
Radiofrequency ablation (RFA), an effective, locally directed therapy for unresectable liver metastases, can improve the survival of patients. As a functional imaging approach, (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) or PET-computed tomography (PET-CT) may play a crucial role in the follow-up after RFA. Our objective was to evaluate the diagnostic accuracy of (18)F-FDG PET or PET-CT for the detection of residual tumor following RFA of liver metastases. Studies reporting the diagnostic value of (18)F-FDG PET or PET-CT for patients with residual tumor after RFA of liver metastases were identified. The methodological quality of these studies was systematically evaluated, and the overall sensitivity and specificity of these data sets are reported. Seven studies involving 155 patients were examined. When (18)F-FDG PET or PET-CT was performed within 2 days of RFA, the overall sensitivity and specificity were 79% [95% confidence interval (CI): 70-87%] and 84% (95% CI: 75-91%), respectively. When (18)F-FDG PET or PET-CT was performed 1 week after treatment, the pooled sensitivity and specificity were 48% (95% CI: 18-79%) and 94% (95% CI: 70-100%), respectively. Finally, when (18)F-FDG PET or PET-CT was performed 3 months after treatment, the pooled sensitivity and specificity were 52% (95% CI: 22-81%) and 94% (95% CI: 70-100%), respectively. Both (18)F-FDG PET and PET-CT are effective in detecting residual tumor following RFA of liver metastases. The ideal time to perform these imaging studies is within 2 days of RFA treatment.
射频消融术（RFA）是一种针对不可切除肝转移瘤的有效局部治疗方法，可提高患者生存率。作为一种功能成像方法，（18）F-氟脱氧葡萄糖正电子发射断层扫描（（18）F-FDG PET）或PET计算机断层扫描（PET-CT）在RFA后的随访中可能起关键作用。我们的目的是评估（18）F-FDG PET或PET-CT对肝转移瘤RFA后残留肿瘤检测的诊断准确性。我们检索了报告（18）F-FDG PET或PET-CT对肝转移瘤RFA后残留肿瘤患者诊断价值的研究。系统评价了这些研究的方法学质量，并报告了这些数据集的总体敏感性和特异性。共纳入7项研究，涉及155例患者。在RFA后2天内进行（18）F-FDG PET或PET-CT检查时，总体敏感性和特异性分别为79%[95%置信区间（CI）：70-87%]和84%（95%CI：75-91%）。在治疗1周后进行（18）F-FDG PET或PET-CT检查时，合并敏感性和特异性分别为48%（95%CI：18-79%）和94%（95%CI：70-100%）。最后，在治疗3个月后进行（18）F-FDG PET或PET-CT检查时，合并敏感性和特异性分别为52%（95%CI：22-81%）和94%（95%CI：70-100%）。（18）F-FDG PET和PET-CT在检测肝转移瘤RFA后残留肿瘤方面均有效。进行这些影像学检查的理想时间是在RFA治疗后2天内。
