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本文引用的文献

1
Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis.软骨硫酸软骨素 N-乙酰半乳糖胺基转移酶 1 和 Hapln-1 在大骨节病和原发性骨关节炎软骨中的异常表达。
Int Orthop. 2013 Oct;37(10):2051-9. doi: 10.1007/s00264-013-1937-y. Epub 2013 Jun 8.
2
Clinical features of Kashin-Beck disease in adults younger than 50 years of age during a low incidence period: severe elbow and knee lesions.在发病率较低的时期,50 岁以下成人的大骨节病临床特征:严重的肘和膝关节病变。
Clin Rheumatol. 2013 Mar;32(3):317-24. doi: 10.1007/s10067-012-2115-0. Epub 2012 Dec 8.
3
A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin-Beck disease of the knee.透明质酸与美洛昔康治疗成人膝关节大骨节病的随机、单盲、对照疗效及耐受性比较
Clin Rheumatol. 2012 Jul;31(7):1079-86. doi: 10.1007/s10067-012-1979-3. Epub 2012 Apr 3.
4
Knee replacement.膝关节置换术。
Lancet. 2012 Apr 7;379(9823):1331-40. doi: 10.1016/S0140-6736(11)60752-6. Epub 2012 Mar 6.
5
Total knee arthroplasty in patients over 80 years of age.80岁以上患者的全膝关节置换术。
J Knee Surg. 2011 Dec;24(4):279-83. doi: 10.1055/s-0031-1284729.
6
Comparison of the Norwegian knee arthroplasty register and a United States arthroplasty registry.挪威膝关节置换登记处与美国关节置换登记处的比较。
J Bone Joint Surg Am. 2011 Dec 21;93 Suppl 3:20-30. doi: 10.2106/JBJS.K.01045.
7
Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck disease (KBD) patients.塞来昔布、美洛昔康和对乙酰氨基酚治疗老年大骨节病(KBD)患者的疗效。
Int Orthop. 2011 Sep;35(9):1409-14. doi: 10.1007/s00264-010-1062-0. Epub 2010 Jun 13.
8
Kashin Beck Disease: more than just osteoarthrosis: a cross-sectional study regarding the influence of body function-structures and activities on level of participation.大骨节病:不仅仅是骨关节炎:一项关于身体功能-结构和活动对参与水平影响的横断面研究。
Int Orthop. 2011 May;35(5):767-76. doi: 10.1007/s00264-010-1043-3. Epub 2010 Jun 11.
9
The Swedish Knee Arthroplasty Register (www.knee.se).瑞典膝关节置换登记处(www.knee.se)。
Acta Orthop. 2010 Feb;81(1):5-7. doi: 10.3109/17453671003667267.
10
Effects of physical environment on the evolution of Kashin-Beck disease in Tibet.西藏自然环境对大骨节病病情演变的影响
Int Orthop. 2009 Aug;33(4):1085-8. doi: 10.1007/s00264-009-0738-9. Epub 2009 Mar 17.

老年膝关节严重 Kashin-Beck 病患者的全膝关节置换术。

Total knee arthroplasty in elderly patients with severe Kashin-Beck disease of the knee.

机构信息

Department of Orthopaedic Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, People's Republic of China.

出版信息

Int Orthop. 2014 Apr;38(4):753-9. doi: 10.1007/s00264-013-2171-3. Epub 2013 Dec 10.

DOI:10.1007/s00264-013-2171-3
PMID:24323348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3971259/
Abstract

PURPOSE

The treatment of elderly KBD knee remains a significant clinical challenge, and clinical data are lacking. This study aimed to prospectively determine the functional outcomes of total knee arthroplasty (TKA) in adult patients with severe Kashin-Beck disease (KBD) of the knee.

METHOD

Fifteen cases that included 18 occurrences of KBD of the knee were treated by primary knee arthroplasty and followed up for at least two years. Clinical assessments for each patient were performed at time zero (pre-operatively), one, three, six and 12 months and yearly thereafter. The efficacy measures included the visual analogue scale (VAS) pain score, Hospital for Special Surgery (HSS) score, and Functional Score for Adult Tibetans with Kashin-Beck Disease (FSAT-KBD) as well as radiographic findings.

RESULTS

All patients were followed for a mean length of 32.47±10.05 months. All force lines in the lower limbs had been improved significantly. No radiographic evidence of loosening or changes in component positioning was observed at the last follow up. The VAS decreased significantly during the first six months after surgery and was maintained until the last follow up (p < 0.01). Similar trends were found in both HSS and FSAT-KBD, which increased significantly post-operatively (p < 0.01).

CONCLUSION

Knee arthroplasty can reduce pain and improve function in patients with severe KBD of the knee. Additional studies will be necessary to confirm our findings.

摘要

目的

老年 KBD 膝关节的治疗仍然是一个重大的临床挑战,且临床数据有限。本研究旨在前瞻性评估全膝关节置换术(TKA)治疗成人严重膝关节 KBD 的功能结果。

方法

15 例(18 个膝关节)患者接受初次膝关节置换术治疗,至少随访 2 年。对每位患者在时间零(术前)、1 个月、3 个月、6 个月和 12 个月以及此后每年进行临床评估。疗效评估包括视觉模拟评分(VAS)疼痛评分、特种外科医院(HSS)评分、成人西藏 KBD 功能评分(FSAT-KBD)以及影像学发现。

结果

所有患者平均随访 32.47±10.05 个月。所有下肢力线均得到显著改善。末次随访时,未观察到任何松动或部件位置改变的影像学证据。术后前 6 个月 VAS 显著下降,直至末次随访(p<0.01)。HSS 和 FSAT-KBD 也有类似的趋势,术后显著增加(p<0.01)。

结论

膝关节置换术可减轻严重膝关节 KBD 患者的疼痛,改善其功能。需要进一步的研究来证实我们的发现。