Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Mol Cell Biol. 2014 Feb;34(4):664-72. doi: 10.1128/MCB.01045-13. Epub 2013 Dec 9.
Wiring between signaling pathways differs according to context, as exemplified by interactions between Notch and epidermal growth factor receptor (EGFR) pathways, which are cooperative in some contexts but antagonistic in others. To investigate mechanisms that underlie different modes of cross talk, we have focused on argos, an EGFR pathway regulator in Drosophila melanogaster which is upregulated by Notch in adult muscle progenitors but is repressed in the wing. Results show that the alternate modes of cross talk depend on the engagement of enhancers with opposite regulatory logic, which are selected by context-determining factors. This is likely to be a general mechanism for enabling the wiring between these pathways to switch according to context.
信号通路之间的连接根据具体情况而有所不同，例如 Notch 和表皮生长因子受体 (EGFR) 通路之间的相互作用，在某些情况下是合作的，而在其他情况下则是拮抗的。为了研究导致不同串扰模式的机制，我们专注于果蝇中的 EGFR 通路调节剂 argos，它在成年肌肉祖细胞中被 Notch 上调，但在翅膀中被抑制。结果表明，不同串扰模式取决于与相反调控逻辑的增强子的结合，这些增强子是由决定因素选择的。这可能是使这些通路之间的连接根据具体情况切换的一般机制。
