Brownridge E, Lopez C
Nat Immun Cell Growth Regul. 1986;5(6):294-304.
Unelicited murine peritoneal cells (PC) were found to efficiently lyse the natural cytotoxic (NC) cell target, WEHI-164, as well as herpes simplex virus-type 1 (HSV-1)-infected WEHI-164 and 3T3 cells but not the natural killer (NK) target, YAC-1. Lysis by PC of HSV-1-infected WEHI-164 and 3T3 cells required longer culture times than splenic cell lysis of YAC-1 cells. The PCs which lysed these targets were found to be slightly adherent to nylon wool but non-phagocytic, and were not augmented by preincubation with interferon. Also, PC effectors lacked Qa-5 and asialo GM1 markers which are found on splenic NK cells which lysed YAC-1 targets. We found that there was no correlation between peritoneal NC activity and genetic resistance to HSV-1.
未经刺激的小鼠腹腔细胞（PC）能有效裂解天然细胞毒性（NC）细胞靶标WEHI-164，以及感染1型单纯疱疹病毒（HSV-1）的WEHI-164和3T3细胞，但不能裂解天然杀伤（NK）靶标YAC-1。PC对感染HSV-1的WEHI-164和3T3细胞的裂解所需培养时间比脾细胞对YAC-1细胞的裂解更长。发现裂解这些靶标的PC对尼龙棉有轻微黏附性但无吞噬作用，且预先用干扰素孵育不能增强其活性。此外，PC效应细胞缺乏Qa-5和脱唾液酸GM1标志物，而在裂解YAC-1靶标的脾NK细胞上可发现这些标志物。我们发现腹腔NC活性与对HSV-1的遗传抗性之间没有相关性。
