Feranec R, Mouková L, Chovanec J
Klin Onkol. 2013;26 Suppl:S52-3. doi: 10.14735/amko2013s52.
Preinvasive lesions of the endometrium are histopathological and molecular alterations related to high-risk of uterine carcinoma development. Incidence has increasing tendency. Atypical endometrial hyperplasia is the preinvasive lesion of type I endometrial carcinoma, developing under a hyperestrogenic background. Carcinoma in situ of the endometrium is considered to be precursor lesion of type II endometrial carcinoma, first of all uterine serous carcinoma. Hysterectomy and bilateral oophorectomy is the main therapeutical modality in both preinvasive lesions of the endometrium. The hormonal therapy with progestogens is the possibility of fertility sparing approach in treatment of histological findings of atypical endometrial hyperplasia in young women. Even though preinvasive lesions of the endometrium are clearly defined, the possibilities of endometrial cancer screening are markedly limited.
子宫内膜的癌前病变是与子宫癌发生高风险相关的组织病理学和分子改变。发病率呈上升趋势。非典型子宫内膜增生是I型子宫内膜癌的癌前病变，在高雌激素背景下发生。子宫内膜原位癌被认为是II型子宫内膜癌的前驱病变，首先是子宫浆液性癌。子宫切除术和双侧卵巢切除术是子宫内膜两种癌前病变的主要治疗方式。孕激素激素治疗是年轻女性非典型子宫内膜增生组织学表现治疗中保留生育功能方法的一种可能性。尽管子宫内膜的癌前病变已明确界定，但子宫内膜癌筛查的可能性明显有限。
