Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California at Davis, Davis, CA 95616, USA.
Mol Cell Endocrinol. 2014 Mar 5;383(1-2):80-95. doi: 10.1016/j.mce.2013.11.015. Epub 2013 Dec 8.
Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.
甲状腺激素受体 (TR) 主要表达为两种主要的异构体，TRα1 和 TRβ1，它们在发育过程中的不同时间表达，并在成年时在不同的组织中丰富表达。TRα1 和 TRβ1 的转录特性和生物学特性可能不同。我们在这里报告，尽管重叠，TRα1 和 TRβ1 招募不同的伙伴蛋白，这可能解释了它们不同的生物学功能，并解释了它们不同的靶基因调节特性。
