Department of Global Health.
J Infect Dis. 2014 May 15;209(10):1623-7. doi: 10.1093/infdis/jit807. Epub 2013 Dec 10.
We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples.
Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls.
TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression.
TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.
我们评估了 Toll 样受体(TLRs)单核苷酸多态性(SNPs)与非洲夫妇 HIV-1 感染、疾病进展的关联。
在 504 例 HIV-1 感染病例和 343 例血清阴性对照中,对 7 个候选 SNP 和 116 个单倍型标签 SNP(tagSNP)进行了基因分型。
TLR9 1635A/G 与 HIV-1 暴露水平较高而非较低的 HIV-血清阴性对照者中 HIV-1 感染减少相关(比值比[OR] = 0.7;P =.03 和 OR = 0.9,P =.5,分别)。TLR7 rs179012 和 TLR2 597C/T 降低了疾病进展的设定点;后者受 HIV-1 感染后时间的影响。TLR8 1A/G 降低了疾病进展速度。
TLR SNPs 对 HIV-1 结局有影响,而流行病学因素则改变了这些关系。