非糖尿病患者中与餐后血糖控制状况相关的尿N-乙酰-β-D-氨基葡萄糖苷酶水平的变化。

Change in urinary N-acetyl-β-d-glucosaminidase levels relevant to postprandial glycemic control conditions in subjects without diabetes mellitus.

作者信息

Ouchi Motoshi, Oba Kenzo, Ohara Makoto, Igari Yoshimasa, Futami-Suda Shoko, Ishii Kazuhito, Aoyama Junya, Onishi Tetsuro, Tsunoda-Kubota Misako, Yamashita Hidetoshi, Suzuki Tatsuya, Nakano Hiroshi

机构信息

Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.

Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan; Department of Internal Medicine, Oarai Sea Shore Core Clinic, Ibaraki, Japan.

出版信息

Clin Chim Acta. 2014 Jun 10;433:88-92. doi: 10.1016/j.cca.2013.11.035. Epub 2013 Dec 8.

DOI:10.1016/j.cca.2013.11.035

PMID:24326128

Abstract

BACKGROUND

To assess the relationship between the serum level of 1,5-anhydroglucitol (1,5-AG), a marker of postprandial hyperglycemia, and the ratio of the urinary activity of N-acetyl-β-d-glucosaminidase to creatinine (NAG index) in subjects without diabetes mellitus (DM).

METHODS

This was a cross-sectional study with 495 subjects without DM who had an estimated glomerular filtration rate≥30ml/min/1.73m(2). Subjects were divided into tertiles based on serum 1,5-AG levels: high (>21.0μg/ml), middle (14.0-21.0μg/ml), and low (<14.0μg/ml). Adjusted odds ratios for an elevated urinary NAG index (>5.8U/g creatinine) according to the HbA1c (≤5.4%, 5.5%-5.9%, and 6.0%-6.4%) and 1,5-AG tertiles were calculated.

RESULTS

The NAG index was negatively correlated with the serum 1,5-AG level in all subjects. The slopes of the regression lines for these variables did not differ significantly between elderly (≥65y) and nonelderly subjects. As compared with high 1,5-AG and HbA1c≤5.4%, the odds ratios for an elevated urinary NAG index increased progressively to 7.71 across the categories of low 1,5-AG and HbA1c of 6.0% to 6.4%.

CONCLUSION

Poor control of postprandial glucose is related to an elevated urinary NAG index in persons without DM.

摘要

背景

评估餐后高血糖标志物1,5-脱水葡萄糖醇（1,5-AG）血清水平与非糖尿病患者尿N-乙酰-β-D-氨基葡萄糖苷酶与肌酐比值（NAG指数）之间的关系。

方法

这是一项横断面研究，纳入495例估算肾小球滤过率≥30ml/min/1.73m²的非糖尿病患者。根据血清1,5-AG水平将受试者分为三分位数：高（>21.0μg/ml）、中（14.0 - 21.0μg/ml）、低（<14.0μg/ml）。计算根据糖化血红蛋白（HbA1c）（≤5.4%、5.5% - 5.9%、6.0% - 6.4%）和1,5-AG三分位数升高的尿NAG指数（>5.8U/g肌酐）的调整比值比。