From the Departments of *Surgery and Oncology, †Anatomic Pathology, and ‡Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Pancreas. 2014 Jan;43(1):1-6. doi: 10.1097/MPA.0b013e3182a71537.
Glucagon-like peptide 1 (GLP-1) interacts with its specific high-affinity receptor, glucagon-like peptide 1 receptor (GLP-1R), and induces cellular growth and inhibition of apoptosis in pancreatic β cells. The aim of this study was to investigate the significance of GLP-1R expression in pancreatic neuroendocrine tumors (PNETs).
Glucagon-like peptide 1 receptor expression was semiquantitatively evaluated by immunohistochemical staining in 50 resected PNETs, and the correlation between the GLP-1R expression and clinicopathologic features was investigated.
There were 23 PNETs with positive expression and 27 PNETs with negative expression of GLP-1R. Positive expression of GLP-1R was more frequently observed in insulinoma than in gastrinoma and nonfunctioning tumor (P < 0.05). Although expression status of GLP-1R did not affect the prognosis of the patients with PNETs (P = 0.82), most of the metastatic sites such as lymph node and liver showed positive staining for GLP-1R (8 of 11 PNETs, 73%).
Glucagon-like peptide 1 receptor would be a diagnostic marker of insulinoma and might become a molecular target for treatment of metastatic PNETs and hormonal regulation of insulin.
胰高血糖素样肽 1（GLP-1）与特异性高亲和力受体胰高血糖素样肽 1 受体（GLP-1R）相互作用，诱导胰岛β细胞的细胞生长和抑制细胞凋亡。本研究旨在探讨 GLP-1R 在胰腺神经内分泌肿瘤（PNETs）中的表达意义。
通过免疫组织化学染色对半定量评估 50 例切除的 PNETs 中 GLP-1R 的表达，并研究 GLP-1R 表达与临床病理特征的相关性。
有 23 例 PNETs 呈 GLP-1R 阳性表达，27 例 PNETs 呈 GLP-1R 阴性表达。胰岛素瘤中 GLP-1R 的阳性表达比胃泌素瘤和无功能肿瘤更常见（P < 0.05）。尽管 GLP-1R 的表达状态并不影响 PNETs 患者的预后（P = 0.82），但大多数转移部位如淋巴结和肝脏对 GLP-1R 呈阳性染色（11 例 PNETs 中的 8 例，73%）。
GLP-1R 可能成为胰岛素瘤的诊断标志物，并可能成为治疗转移性 PNETs 和胰岛素激素调节的分子靶点。
