Katikaneni Ranjitha, Gulati Rohan, Suh Daniel, Sakon Joshua, Seymour Andrew, Ponnapakkam Tulasi, Gensure Robert
Department of Pediatric Endocrinology, Children's Hospital at Montefiore, Bronx, New York, USA.
J Investig Dermatol Symp Proc. 2013 Dec;16(1):S61-2. doi: 10.1038/jidsymp.2013.25.
Alopecia areata is a common form of hair loss in which autoimmune-mediated destruction of hair follicles causes patchy hair loss, for which there is no adequate therapy. Parathyroid hormone (PTH) induces the hair cycle and promotes hair growth. PTH-CBD is a fusion protein of PTH and a bacterial collagen-binding domain (CBD), leading to targeted delivery to and retention in the skin collagen. We tested the effects of a single dose of PTH-CBD (low or high dose) on an animal model for alopecia areata, the C3H/HeJ engrafted mouse. In all the treated animals, there was a rapid (1-4 days) increase in hair growth, with sustained effects observed over a 2-month period (7/10 total treated mice<40% hair loss based on gray scale analysis, vs. 2/5 in vehicle control animals). Histological examination revealed massive stimulation of anagen VI hair follicles in treated animals despite an ongoing immune response. PTH-CBD thus shows promise as a therapy for alopecia areata, likely in conjunction with a mild immune suppressant, such as hydrocortisone cream.
斑秃是一种常见的脱发形式，其中自身免疫介导的毛囊破坏导致斑秃，对此尚无足够的治疗方法。甲状旁腺激素（PTH）可诱导毛发周期并促进头发生长。PTH-CBD是PTH与细菌胶原结合域（CBD）的融合蛋白，可靶向递送至皮肤胶原蛋白并保留在其中。我们测试了单剂量PTH-CBD（低剂量或高剂量）对斑秃动物模型C3H/HeJ移植小鼠的影响。在所有接受治疗的动物中，毛发生长迅速（1-4天）增加，在2个月的时间内观察到持续效果（基于灰度分析，10只接受治疗的小鼠中有7只脱发<40%，而载体对照动物中为5只中有2只）。组织学检查显示，尽管存在持续的免疫反应，但治疗动物中的生长期VI毛囊受到大量刺激。因此，PTH-CBD有望成为治疗斑秃的方法，可能与轻度免疫抑制剂（如氢化可的松乳膏）联合使用。
