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[一只感染管圆线虫的犬发生弥散性血管内凝血]

[Disseminated intravascular coagulopathy in a dog with Angiostrongylus vasorum infection].

作者信息

Kruse B D, Hartmann K, Groth A, Schulz B, Wehner A

机构信息

Dr. Astrid Wehner, Dipl. ECVIM-CA Innere Medizin, Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 München, E-Mail:

出版信息

Tierarztl Prax Ausg K Kleintiere Heimtiere. 2013;41(6):401-7.

Abstract

A 2-year-old female spayed Epagneul-Breton dog was presented with ecchymoses, but an undisturbed general condition. Clinical examination additionally revealed petechia and a haematoma. Travel history included Italy and Denmark. Laboratory abnormalities were moderate thrombocytopenia, prolonged PT, aPTT and TT, and elevated d-dimers. Initial therapy consisted of plasma transfusions, fluids, doxycycline and famotidine administration. Babesiosis, ehrlichiosis, leishmaniosis, dirofilariosis or anaplasmosis could not be confirmed. Abdominal ultrasound was unremarkable, while thoracic radiographs showed a bronchointerstitial pattern. Faecal samples collected over 3 days were positive for Angiostrongylus vasorum after examination using the Baermann lungworm test. The A. vasorum infection was successfully treated with fenbendazole, whereupon thrombocytopenia and prolonged coagulation times were resolved. In regions of low prevalence, an infection with A. vasorum should also be considered as a differential diagnosis in dogs with coagulation abnormalities. Respiratory signs can be absent with this disease. The patient may have acquired the infection abroad or in Germany.

摘要

一只2岁已绝育的不列塔尼猎犬雌性犬出现瘀斑,但一般状况未受影响。临床检查还发现有瘀点和血肿。旅行史包括意大利和丹麦。实验室检查异常包括中度血小板减少、凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)和凝血酶时间(TT)延长,以及D - 二聚体升高。初始治疗包括输血、补液、给予强力霉素和法莫替丁。巴贝斯虫病、埃立克体病、利什曼病、恶丝虫病或无形体病均未得到证实。腹部超声检查未见异常,而胸部X光片显示支气管间质型。使用贝尔曼氏肺吸虫试验对连续3天采集的粪便样本进行检查,结果显示血管圆线虫呈阳性。血管圆线虫感染经芬苯达唑成功治疗,随后血小板减少和凝血时间延长的情况得到缓解。在患病率较低的地区,血管圆线虫感染也应被视为患有凝血异常的犬的鉴别诊断之一。这种疾病可能没有呼吸道症状。该患者可能在国外或德国感染此病。

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