Jamsen Kris M, McLeay Sarah C, Barras Michael A, Green Bruce
Model Answers Pty Ltd, Suites 3-4, 333 Ann St, Brisbane, QLD, 4000, Australia,
Clin Pharmacokinet. 2014 Feb;53(2):111-22. doi: 10.1007/s40262-013-0114-1.
The key purpose of performing pharmacometric research is to aid optimization of drug dosing strategies. The statistical techniques required for this research are advanced, which can make interpretation of results difficult to convey to the target audience if they are unfamiliar with pharmacometric concepts. This article provides a basic guide for authors who wish to publish pharmacometric analyses in peer-reviewed journals. This guide is intended to enhance the readability, reproducibility and understanding of the work for a general readership, which may include clinicians, pharmacists and pharmacometricians. Presentation techniques and examples are offered, as well as a checklist of suggested contents for the manuscript.
进行药代动力学研究的关键目的是帮助优化给药策略。这项研究所需的统计技术很先进，如果目标受众不熟悉药代动力学概念，就难以向他们传达结果的解释。本文为希望在同行评审期刊上发表药代动力学分析的作者提供了基本指南。本指南旨在提高普通读者对该研究的可读性、可重复性和理解度，这些读者可能包括临床医生、药剂师和药代动力学家。文中提供了展示技巧和示例，以及手稿建议内容的清单。
