Bussel J B, Cunningham-Rundles C, Abraham C
Vox Sang. 1986;51(4):264-9. doi: 10.1111/j.1423-0410.1986.tb01967.x.
Autoimmune hemolytic anemia (AIHA) has been considered to be unresponsive to intravenous gammaglobulin (IVGG) at the doses that are effective in immune thrombocytopenic purpura and autoimmune neutropenia (usually 2 g/kg total dose). This study reports the use of a higher dose (5 g/kg total dose over 5 days) in four severe cases of AIHA which resulted in a sustained remission in two patients, a transient response in the third, and a failure in the forth patient. These data suggest that larger quantities of IVGG may be needed in this disease, possibly because the reticuloendothelial system appears to be enlarged in AIHA patients.
自身免疫性溶血性贫血（AIHA）被认为对在免疫性血小板减少性紫癜和自身免疫性中性粒细胞减少症中有效的剂量（通常总剂量为2g/kg）的静脉注射丙种球蛋白（IVGG）无反应。本研究报告了对4例严重AIHA患者使用更高剂量（5天内总剂量为5g/kg）的情况，结果2例患者持续缓解，第3例患者有短暂反应，第4例患者治疗失败。这些数据表明，这种疾病可能需要更大剂量的IVGG，这可能是因为AIHA患者的网状内皮系统似乎增大了。
