Connell Timothy U, Hayne David J, Ackermann Uwe, Tochon-Danguy Henri J, White Jonathan M, Donnelly Paul S
School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, 3010, Australia.
J Labelled Comp Radiopharm. 2014 Apr;57(4):262-9. doi: 10.1002/jlcr.3169. Epub 2013 Dec 11.
New 1,4-substituted pyridyl-1,2,3-triazole ligands with pendent phenyl isothiocyanate functional groups linked to the heterocycle through a short methylene or longer polyethylene glycol spacers were prepared and conjugated to a peptide containing the arginine-glycine-aspartic acid peptide motif. Rhenium and technetium carbonyl complexes, M(CO)3 L(x) (py) (where M = Re(I) or (99m) Tc(I) ; L(x) = 1,4-substituted pyridyl-1,2,3-triazole ligands and py = pyridine) were prepared. One rhenium complex has been characterized by X-ray crystallography, and the luminescent properties of M(CO)3 L(x) (py) are reported.
制备了新型的1,4-取代吡啶基-1,2,3-三唑配体，其通过短亚甲基或更长的聚乙二醇间隔基与杂环相连，带有苯异硫氰酸酯官能团，并与含有精氨酸-甘氨酸-天冬氨酸肽基序的肽共轭。制备了铼和锝羰基配合物[M(CO)₃L(x)(py)]⁺（其中M = Re(I)或⁹⁹ᵐTc(I)；L(x) = 1,4-取代吡啶基-1,2,3-三唑配体，py = 吡啶）。一种铼配合物已通过X射线晶体学进行了表征，并报道了[M(CO)₃L(x)(py)]⁺的发光性质。
