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Fitness gains hamper efforts to tackle drug resistance.

作者信息

Dutta Shanta

机构信息

Shanta Dutta is in the Bacteriology Division, National Institute of Cholera and Enteric Diseases, Kolkata, India

出版信息

Elife. 2013 Dec 10;2:e01809. doi: 10.7554/eLife.01809.

DOI:10.7554/eLife.01809
PMID:24327563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3857915/
Abstract

It has long been assumed that resistance to antibiotics reduces the fitness of disease-causing bacteria, but experiments on Salmonella Typhi, the bacteria that causes Typhoid fever, are now challenging this view.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ad/3857915/9cf4d91e52b7/elife01809f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ad/3857915/9cf4d91e52b7/elife01809f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38ad/3857915/9cf4d91e52b7/elife01809f001.jpg

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本文引用的文献

1
Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure.在无抗菌压力情况下，耐氟喹诺酮伤寒沙门氏菌的适应性益处。
Elife. 2013 Dec 10;2:e01229. doi: 10.7554/eLife.01229.
2
Antibiotic resistance and its cost: is it possible to reverse resistance?抗生素耐药性及其代价：逆转耐药性是否可行？
Nat Rev Microbiol. 2010 Apr;8(4):260-71. doi: 10.1038/nrmicro2319. Epub 2010 Mar 8.
3
Treatment of enteric fever.伤寒的治疗。
BMJ. 2009 Jun 3;338:b1159. doi: 10.1136/bmj.b1159.
4
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans.上位性：其含义、非含义以及在人类中检测它的统计方法。
Hum Mol Genet. 2002 Oct 1;11(20):2463-8. doi: 10.1093/hmg/11.20.2463.
5
Bacterial evolution and the cost of antibiotic resistance.细菌进化与抗生素耐药性的代价。
Int Microbiol. 1998 Dec;1(4):265-70.