Fisher Monica A, Ma Zhen-Qiang
Pennsylvania Department of Health, Harrisburg, PA, USA.
J Prim Care Community Health. 2014 Apr 1;5(2):112-21. doi: 10.1177/2150131913503347. Epub 2013 Sep 10.
Multiple chronic conditions (MCCs) are significant public health problems receiving much attention, and rightly so, because of the substantial morbidity, mortality, and cost burden.
To report the prevalence of selected frequent MCCs with shared risk factors that are leading causes of death; and to quantify the association between diabetes and its comorbidity and shared risk factors.
This is a cross-sectional study of 9172 participants in Pennsylvania's 2009 Behavioral Risk Factor Surveillance System (BRFSS). Centers for Disease Control and Prevention's Web Enabled Analysis Tool (WEAT) and SAS Proc Survey were used for all analyses, to account for BRFSS's multistage complex survey design and sample weights.
SAS estimated prevalence among ≥35-year-olds were as follows: diabetes (11.9%), heart disease (9.5%), stroke (3.3%), diabetes and heart disease (2.9%), diabetes and stroke (1.0%), heart disease and stroke (1.1%), and diabetes, heart disease, and stroke (0.4%). Adults ≥35 years old with the following characteristics were more likely to have diabetes when self-reporting: obese (adjusted odds ratio [ORAdj] = 4.63, 95% confidence interval [95% CI] = 3.41-6.30); low income (<$15 000 ORAdj = 2.85, 95% CI = 1.90-4.27; $15 000-$24 999 ORAdj = 2.07, 95% CI = 1.50-2.86; $25 000-$34 999 ORAdj = 2.06, 95% CI = 1.47-2.88; $35 000-$49 999 ORAdj = 1.51, 95% CI = 1.08-2.12); elderly ≥65 years old (ORAdj = 2.84, 95% CI = 1.76-4.56); non-Hispanic black (ORAdj = 2.54, 95% CI = 1.08-6.00); overweight (ORAdj = 1.99, 95% CI = 1.47-2.68); heart disease (ORAdj = 1.94, 95% CI = 1.47-2.56); 45 to 64 years old (ORAdj = 1.88 95%, CI = 1.21-2.93); hypertension (ORAdj = 1.78, 95% CI = 1.39-2.29); stroke (ORAdj = 1.62, 95% CI = 1.05-2.50); high cholesterol (ORAdj = 1.49, 95% CI = 1.18-1.88); physically inactive (ORAdj = 1.33 95% CI = 1.06-1.67); and men (ORAdj = 1.32, 95% CI = 1.04-1.67).
Adults with comorbidity and risk factors were 1.3 to 4.6 times more likely to have diabetes, with obesity consistently the strongest risk factor. WEAT's limitations are the predefined categories, inability to restrict to specific age groups and to estimate the prevalence of >2 MCCs. WEAT has considerable potential to advance evidence-based primary care practice and community health programs, such as state-wide programs that target obesity and physical inactivity. The robust capability of SAS to calculate MCC prevalence and adjusted associations with risk factors provides the fundamentals for developing and evaluating primary care services and community health programs.
多种慢性病(MCCs)是重大的公共卫生问题,因其引发的大量发病、死亡和成本负担而备受关注,这是理所当然的。
报告具有共同风险因素且为主要死因的特定常见MCCs的患病率;并量化糖尿病与其合并症及共同风险因素之间的关联。
这是一项对宾夕法尼亚州2009年行为危险因素监测系统(BRFSS)中9172名参与者的横断面研究。所有分析均使用疾病控制与预防中心的网络分析工具(WEAT)和SAS统计分析软件的调查程序,以考虑BRFSS的多阶段复杂调查设计和样本权重。
SAS估计35岁及以上人群的患病率如下:糖尿病(11.9%)、心脏病(9.5%)、中风(3.3%)、糖尿病和心脏病(2.9%)、糖尿病和中风(1.0%)、心脏病和中风(1.1%)以及糖尿病、心脏病和中风(0.4%)。自我报告时,具有以下特征的35岁及以上成年人更易患糖尿病:肥胖(调整后的优势比[ORAdj]=4.63,95%置信区间[95%CI]=3.41 - 6.30);低收入(<$15000,ORAdj = 2.85,95%CI = 1.90 - 4.27;$15000 - $24999,ORAdj = 2.07,95%CI = 1.50 - 2.86;$25000 - $34999,ORAdj = 2.06,95%CI = 1.47 - 2.88;$35000 - $49999,ORAdj = 1.51,95%CI = 1.08 - 2.12);65岁及以上老年人(ORAdj = 2.84,95%CI = 1.76 - 4.56);非西班牙裔黑人(ORAdj = 2.54,95%CI = 1.08 - 6.00);超重(ORAdj = 1.99,95%CI = 1.47 - 2.68);心脏病(ORAdj = 1.94,95%CI = 1.47 - 2.56);45至64岁(ORAdj = 1.88,95%CI = 1.21 - 2.93);高血压(ORAdj = 1.78,95%CI = 1.39 - 2.29);中风(ORAdj = 1.62,95%CI = 1.05 - 2.50);高胆固醇(ORAdj = 1.49,95%CI = 1.18 - 1.88);缺乏身体活动(ORAdj = 1.33,95%CI = 1.06 - 1.67);以及男性(ORAdj = 1.32,95%CI = 1.04 - 1.67)。
患有合并症和风险因素的成年人患糖尿病的可能性是常人的1.3至4.6倍,肥胖始终是最强的风险因素。WEAT的局限性在于预定义类别、无法限制于特定年龄组以及无法估计超过两种MCCs的患病率。WEAT在推进基于证据的初级保健实践和社区健康项目方面具有相当大的潜力,例如针对肥胖和身体活动不足的全州范围项目。SAS强大的计算MCC患病率以及与风险因素调整关联的能力为制定和评估初级保健服务及社区健康项目提供了基础。