Institute of Functional Interfaces (IFG), ‡Soft Matter Synthesis Lab, Institute for Biological Interfaces (IBG), and §Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT) , Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
J Am Chem Soc. 2014 Jan 8;136(1):8-11. doi: 10.1021/ja409205s. Epub 2013 Dec 16.
We report the fabrication of 3D, highly porous, covalently bound polymer films of homogeneous thickness. These surface-bound gels combine the advantages of metal-organic framework (MOF) materials, namely, the enormous flexibility and the large size of the maximum pore structures and, in particular, the possibility to grow them epitaxially on modified substrates, with those of covalently connected gel materials, namely, the absence of metal ions in the deposited material, a robust framework consisting of covalent bonds, and, most importantly, pronounced stability under biological conditions. The conversion of a SURMOF (surface-mounted MOF) yields a surface-grafted gel. These SURGELs can be loaded with bioactive compounds and applied as bioactive coatings and provide a drug-release platform in in vitro cell culture studies.
我们报告了 3D、高多孔、共价键合的聚合物薄膜的制造，这些薄膜具有均匀的厚度。这些表面结合的凝胶结合了金属有机骨架（MOF）材料的优势，即最大孔结构的巨大灵活性和大尺寸，特别是能够在经过修饰的基底上外延生长，以及共价连接的凝胶材料的优势，即沉积材料中没有金属离子、由共价键组成的坚固框架，以及在生物条件下最重要的是明显的稳定性。SURMOF（表面安装的 MOF）的转化得到了表面接枝的凝胶。这些 SURGEL 可以负载生物活性化合物，并用作生物活性涂层，并在体外细胞培养研究中提供药物释放平台。
