Department of Obstetrics & Gynecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany.
Future Oncol. 2014 Jan;10(1):41-8. doi: 10.2217/fon.13.174.
Disseminated tumor cell (DTC) detection in bone marrow (BM) of primary breast cancer patients predicts poor prognosis. This study investigates the prevalence of DTCs and their prognostic significance in primary gynecologic malignancies.
PATIENTS & METHODS: DTCs from BM aspirates of 603 patients with endometrial (311), cervical (228) and vulvar cancer (64) were identified by the pancytokeratin antibody A45B/B3.
DTCs were detected in 18% of BM aspirates (21, 16 and 16% in endometrial, cervical and vulvar cancer, respectively). In cervical cancer, DTCs were associated with International Federation of Gynecology and Obstetrics stage, nodal status and lymphangiosis. There was no association between BM status and prognosis.
Tumor cell dissemination is common in gynecological cancer. In contrast to breast cancer, DTCs that derive from cervical, endometrial or vulvar cancer have less potential to initiate metastatic regrow. The molecular mechanisms underlying this observation warrant further investigation.
原发性乳腺癌患者骨髓中播散肿瘤细胞（DTC）的检测可预测不良预后。本研究调查了原发性妇科恶性肿瘤中 DTC 的发生率及其预后意义。
通过使用泛细胞角蛋白抗体 A45B/B3 鉴定了 603 例子宫内膜癌（311 例）、宫颈癌（228 例）和外阴癌（64 例）患者骨髓抽吸物中的 DTC。
骨髓抽吸物中检测到 DTC 的比例为 18%（子宫内膜癌、宫颈癌和外阴癌中分别为 21%、16%和 16%）。在宫颈癌中，DTC 与国际妇产科联合会分期、淋巴结状态和淋巴管浸润有关。骨髓状态与预后之间无关联。
肿瘤细胞播散在妇科癌症中很常见。与乳腺癌不同，源自宫颈癌、子宫内膜癌或外阴癌的 DTC 引发转移复发的潜力较小。这一观察结果背后的分子机制值得进一步研究。
