Jin Yuanzhe, Wang Qi, Wang Guofeng, Zhang Xueying, Yan Bin, Hu Weina
Department of Cardiology, The Fourth Affiliated Hospital of China Medical University , Shenyang, People's Republic of China .
Genet Test Mol Biomarkers. 2014 Mar;18(3):164-73. doi: 10.1089/gtmb.2013.0407. Epub 2013 Dec 13.
ATP-binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression of cardiovascular disease. Emerging evidence suggests that common functional polymorphisms in the ABCB1 gene might have an impact on an individual's susceptibility to coronary heart disease (CHD), but individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between ABCB1 C3435T polymorphism and CHD risk.
An extensive literary search for relevant studies was conducted in PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases from their inception through August 1st, 2013. Meta-analysis was performed using the STATA 12.0 software. The crude odds ratio (OR) with 95% confidence interval (CI) were calculated.
Seven clinical studies were included with a total of 13,074 CHD patients, including 378 variant angina pectoris (VAP) patients, 2290 myocardial infarction (MI) patients, and 10,406 acute coronary syndrome (ACS) patients. Our meta-analysis results indicated that ABCB1 C3435T polymorphism may be associated with an increased risk of CHD, especially for MI and ACS among Caucasian populations. However, no statistically significant association was found between ABCB1 C3435T polymorphism and VAP risk, especially among Asian populations. Meta-regression analyses showed that clinical subtype and ethnicity may be the main sources of heterogeneity. No publication bias was detected in this meta-analysis.
The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute to the risk of CHD, especially for MI and ACS, among Caucasian populations. Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for the early detection of CHD.
ATP结合盒转运体1（ABCB1）在心血管疾病的发生和发展中起关键作用。新出现的证据表明，ABCB1基因常见的功能多态性可能会影响个体患冠心病（CHD）的易感性，但个别发表的结果尚无定论。本荟萃分析旨在更精确地估计ABCB1基因C3435T多态性与冠心病风险之间的关系。
从PubMed、Embase、Web of Science、Cochrane图书馆、CISCOM、CINAHL、谷歌学术、中国生物医学数据库（CBM）和中国知网数据库（CNKI）自创建至2013年8月1日进行了广泛的文献检索，以查找相关研究。使用STATA 12.0软件进行荟萃分析。计算了粗比值比（OR）及95%置信区间（CI）。
纳入了7项临床研究，共13074例冠心病患者，包括378例变异型心绞痛（VAP）患者、2290例心肌梗死（MI）患者和10406例急性冠状动脉综合征（ACS）患者。我们的荟萃分析结果表明，ABCB1基因C3435T多态性可能与冠心病风险增加有关，尤其是在白种人群中的MI和ACS患者。然而，未发现ABCB1基因C3435T多态性与VAP风险之间存在统计学显著关联，尤其是在亚洲人群中。荟萃回归分析表明，临床亚型和种族可能是异质性的主要来源。本荟萃分析未检测到发表偏倚。
当前的荟萃分析表明，ABCB1基因C3435T多态性可能会增加白种人群患冠心病的风险，尤其是MI和ACS患者。因此，检测ABCB1基因C34
