Li Y L, Tian Z, Zhao L, Zhang C L
Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China
Department of General Surgery, The Shengjing Affiliated Hospital of China Medical University, Shenyang, China.
Genet Mol Res. 2014 Oct 7;13(4):8066-79. doi: 10.4238/2014.October.7.1.
Emerging evidence suggests that a common functional polymorphism, rs4444903 (A>G), in the EGF gene might impact an individual's susceptibility to liver cancer; however, individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between the EGF rs4444903 polymorphism and liver cancer risk. A literature search was conducted in the PubMed, Embase, Web of Science, and CBM databases from inception through May 1st, 2013. Seven case-control studies were included with a total of 1408 liver cancer cases and 1343 healthy controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Our meta-analysis results indicated that the G variant of the rs4444903 polymorphism might be associated with an increased risk of liver cancer (G allele vs A allele: OR = 1.25, 95%CI = 1.01-1.56, P = 0.040; GG + AG vs AA: OR = 1.65, 95%CI = 1.27-2.15, P < 0.001; GG vs AA: OR = 1.77, 95%CI = 1.34-2.35, P < 0.001). Further subgroup analysis by ethnicity also showed significant associations between the G variant of the rs4444903 polymorphism and an increased risk of liver cancer among Asian, Caucasian, and African populations. No publication bias was detected in this meta-analysis. In conclusion, the current meta-analysis suggests that the G variant of the rs4444903 polymorphism may increase the risk of liver cancer. The EGF rs4444903 (A>G) polymorphism can be useful as a biomarker in predicting the development of liver cancer.
新出现的证据表明，表皮生长因子（EGF）基因中一种常见的功能性多态性rs4444903（A>G）可能会影响个体患肝癌的易感性；然而，单独发表的结果尚无定论。本荟萃分析旨在更精确地评估EGF rs4444903多态性与肝癌风险之间的关系。我们在PubMed、Embase、Web of Science和中国生物医学文献数据库（CBM）中进行了文献检索，检索时间从各数据库建库至2013年5月1日。纳入了7项病例对照研究，共1408例肝癌病例和1343例健康对照。计算了粗比值比（OR）及95%置信区间（CI）。我们的荟萃分析结果表明，rs4444903多态性的G变体可能与肝癌风险增加相关（G等位基因与A等位基因：OR = 1.25，95%CI = 1.01 - 1.56，P = 0.040；GG + AG与AA：OR = 1.65，95%CI = 1.27 - 2.15，P < 0.001；GG与AA：OR = 1.77，95%CI = 1.34 - 2.35，P < 0.001）。按种族进行的进一步亚组分析也显示，rs4444903多态性的G变体与亚洲、白种人和非洲人群患肝癌风险增加之间存在显著关联。本荟萃分析未检测到发表偏倚。总之，当前的荟萃分析表明，rs4444903多态性的G变体可能会增加患肝癌的风险。EGF rs4444903（A>G）多态性可作为预测肝癌发生的生物标志物。
