Departments of 1Physiology, 2Laboratory Medicine, and 3Radiology, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, South Korea.
Cancer Invest. 2014 Jan;32(1):22-9. doi: 10.3109/07357907.2013.861473. Epub 2013 Dec 14.
Little is known about the biological role of human mammaglobin (hMAM) that is considered as a promising marker for breast cancer. Here, we investigated hMAM's role related to migration and invasion of human breast cancer cells (hBCC). Compared to normal cells, hBCC have high MAM mRNA expression levels. Of the hBCC tested, MAM mRNA expression levels were higher in noninvasive than in invasive cells. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. Taken together, these results suggest that metastasis of hBCC could be controlled by hMAM expression levels.
关于人乳球蛋白（hMAM）的生物学作用知之甚少，它被认为是乳腺癌有前途的标志物。在这里，我们研究了 hMAM 与人类乳腺癌细胞（hBCC）迁移和侵袭相关的作用。与正常细胞相比，hBCC 的 MAM mRNA 表达水平较高。在测试的 hBCC 中，非侵袭性细胞的 MAM mRNA 表达水平高于侵袭性细胞。在乳腺癌细胞中过表达 hMAM 可降低迁移和侵袭能力，而 hMAM 的敲低则增加了迁移和侵袭能力。总之，这些结果表明，hBCC 的转移可以通过 hMAM 的表达水平来控制。
