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用一种寡脱氧核苷酸封闭物阻断 STAT3 信号通路可抑制人卵巢癌细胞的生长。

Blockage of STAT3 signaling pathway with a decoy oligodeoxynucleotide inhibits growth of human ovarian cancer cells.

机构信息

Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.

出版信息

Cancer Invest. 2014 Jan;32(1):8-12. doi: 10.3109/07357907.2013.861471. Epub 2013 Dec 14.

DOI:10.3109/07357907.2013.861471
PMID:24328557
Abstract

Transcription factor decoy oligodeoxynucleotides (ODN) represent a novel tool for targeted inhibition of the STAT3 signaling pathway. To investigate its therapeutic potential in ovarian cancer, a double-stranded decoy ODN mimicking STAT3-specific cis-elements was transfected into two ovarian cancer cell lines OVCAR3 and SKOV3. The STAT3 decoy ODN treatment specifically blocked STAT3 signaling, and inhibited cell proliferation by inducing apoptosis and cell cycle arrest. These results suggest that targeted blockade of the STAT3 signaling pathway with a decoy ODN may represent a potential therapeutic approach in the treatment of ovarian cancer.

摘要

转录因子诱饵寡核苷酸 (ODN) 代表了一种靶向抑制 STAT3 信号通路的新型工具。为了研究其在卵巢癌中的治疗潜力，我们将双链诱饵 ODN 转染到两种卵巢癌细胞系 OVCAR3 和 SKOV3 中，该 ODN 模拟 STAT3 特异性顺式元件。STAT3 诱饵 ODN 处理特异性阻断 STAT3 信号，并通过诱导细胞凋亡和细胞周期停滞抑制细胞增殖。这些结果表明，用诱饵 ODN 靶向阻断 STAT3 信号通路可能代表了治疗卵巢癌的一种潜在治疗方法。

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