Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Cerrahpasa Medical Faculty .
Gynecol Endocrinol. 2014 Feb;30(2):130-4. doi: 10.3109/09513590.2013.867320. Epub 2013 Dec 16.
The relation of antimullerian hormone (AMH) levels with the clinical and biochemical markers of polycystic ovary syndrome (PCOS) could be different. A total of 463 PCOS patients were evaluated in this cross-sectional study. Groups were constructed according to polycystic ovarian morphology (PCOM) and menstrual cycle-length. The relation of serum AMH with androgenic hormones, menstrual cycle-length and clinical signs of PCOS were investigated. A powerful positive relation was found between the PCOM and AMH levels (odds ratio = 2.49). There was a negative correlation between age and AMH level (p < 0.001, r[correlation coefficent] = -0.155). Positive correlations were found between luteinizing hormone (LH) and AMH (p < 0.001, r = 0.25) and also between cycle length and AMH (p < 0.01, r = 0.27). We found a negative week correlation between AMH and follicle-stimulating hormone (FSH) (p = 0.01, r = -0.19). After controlling main androgenic hormones, AMH was found to be correlated with the Ferriman-Gallway score (p = 0.03, r = 0.18). There was a positive relationship between hirsutism and AMH (odds ratio = 1.43), but no correlation between AMH and other parameters of clinical hyperandrogenism like hair-loss, acne and seborrhea were identified. The strongest relation was presented between the AMH levels and PCOM. Also, cycle-length correlated well with the AMH levels. The relationship between hirsutism and AMH is found to be independent from androgenic hormones.
抗缪勒管激素（AMH）水平与多囊卵巢综合征（PCOS）的临床和生化标志物的关系可能不同。本横断面研究共评估了 463 例 PCOS 患者。根据多囊卵巢形态（PCOM）和月经周期长度构建了组。研究了血清 AMH 与雄激素、月经周期长度和 PCOS 临床体征的关系。发现 PCOM 与 AMH 水平之间存在强大的正相关关系（优势比=2.49）。年龄与 AMH 水平呈负相关（p<0.001，r[相关系数]=-0.155）。黄体生成素（LH）与 AMH 之间存在正相关（p<0.001，r=0.25），周期长度与 AMH 之间也存在正相关（p<0.01，r=0.27）。我们发现 AMH 与卵泡刺激素（FSH）之间呈负相关（p=0.01，r=-0.19）。在控制主要雄激素后，发现 AMH 与 Ferriman-Gallway 评分相关（p=0.03，r=0.18）。多毛症与 AMH 呈正相关（优势比=1.43），但未发现 AMH 与脱发、痤疮和皮脂溢等其他临床高雄激素参数之间存在相关性。AMH 水平与 PCOM 之间存在最强的关系。此外，月经周期长度与 AMH 水平也很好地相关。发现多毛症与 AMH 之间的关系独立于雄激素。
