含氮呋喃糖核苷酸的合成及其作为酶探针的应用。

Synthesis of nitrogen-containing furanose sugar nucleotides for use as enzymatic probes.

机构信息

Alberta Glycomics Centre and Department of Chemistry, Gunning-Lemieux Chemistry Centre, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.

出版信息

Org Lett. 2014 Jan 3;16(1):212-5. doi: 10.1021/ol4032073. Epub 2013 Dec 16.

DOI:10.1021/ol4032073

PMID:24328953

Abstract

The sugar nucleotides UDP-2-acetamido-2-deoxy-α-D-galactofuranose (UDP-GalfNAc) and UDP-2-azido-2-deoxy-α-D-galactofuranose (UDP-GalfN3) have been synthesized in preparative scale for the first time. These compounds are useful probes for studying the biosynthesis of glycans containing galactofuranose and/or 2-acetamido-2-deoxy-α-D-galactofuranose residues.

摘要

首次以制备规模合成了糖核苷酸 UDP-2-乙酰氨基-2-去氧-α-D-半乳糖呋喃糖（UDP-GalfNAc）和 UDP-2-叠氮-2-去氧-α-D-半乳糖呋喃糖（UDP-GalfN3）。这些化合物是研究含有半乳糖呋喃糖和/或 2-乙酰氨基-2-去氧-α-D-半乳糖呋喃糖残基的聚糖生物合成的有用探针。