研究中的 μ 和 δ 阿片受体激动肽和拟肽类在缓解疼痛中的作用。
Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain.
机构信息
University of Arizona, Department of Chemistry and Biochemistry , 1306 East University Boulevard, PO Box 210041, Tucson, AZ 85721 , USA
出版信息
Expert Opin Investig Drugs. 2014 Feb;23(2):227-41. doi: 10.1517/13543784.2014.856879. Epub 2013 Dec 13.
Abstract
INTRODUCTION
Current methods for treating prolonged and neuropathic pain are inadequate and lead to toxicities that greatly diminish quality of life. Therefore, new approaches to the treatment of pain states are needed to address these problems.
AREAS COVERED
The review primarily reviews approaches that have been taken in the peer-reviewed literature of multivalent ligands that interact with both μ and δ opioid receptors as agonists, and in some cases, also with pharmacophores for antagonist ligands that interact with other receptors as antagonists to block pain.
EXPERT OPINION
Although there are a number of drugs currently on the market for the treatment of pain; none of them are 100% successful. In the authors' opinion, it is clear that new directions and modalities are needed to better address the treatment of prolonged and neuropathic pain; one drug or class clearly is not the answer for all pain therapy. Undoubtedly, there are many different phenotypes of prolonged and neuropathic pain and this should be one avenue to further develop appropriate therapies.
摘要
简介
目前治疗慢性和神经性疼痛的方法并不完善，会导致毒性反应，极大地降低生活质量。因此，需要采用新的方法来治疗疼痛状态，以解决这些问题。
涵盖领域
本综述主要回顾了同行评议文献中关于与 μ 和 δ 阿片受体同时作为激动剂相互作用的多价配体的方法，在某些情况下，还涉及与其他受体相互作用的拮抗剂配体的药效团作为拮抗剂来阻断疼痛。
专家意见
尽管目前有许多药物可用于治疗疼痛，但没有一种药物是 100%有效的。作者认为，很明显，需要新的方向和模式来更好地治疗慢性和神经性疼痛；显然，一种药物或一类药物并不是所有疼痛治疗的答案。毫无疑问，有许多不同表型的慢性和神经性疼痛，这应该是进一步开发适当治疗方法的一个途径。
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