Konstantinova M S, Gromova E A, Bobkova N V, Polenov A L, Plakkhinas L A
Biull Eksp Biol Med. 1986 Dec;102(12):700-1.
For 6 months the rats were kept on 20 degrees ethanol. Then, the rats could choose whether to drink alcohol (A) or water. The rats formed 2 groups: those preferring A and those preferring water. The control rats were kept on water. The function of hypothalamus monoamine- and peptidergic systems were disturbed following chronic A treatment. Alcohol-preferring, unlike water-preferring rats, have revealed higher hypothalamus levels of serotonin and lower levels of dopamine and noradrenaline, which correlated with changes in fluorescence intensity of hypothalamus noradrenaline structures and were accompanied by remarkable disturbances in nonapeptide neurohormone transport in the paraventricular nucleus region.
将大鼠置于含20度乙醇的环境中6个月。然后，大鼠可以选择饮用酒精（A）或水。大鼠形成两组：偏好A组和偏好水组。对照大鼠只给水。长期给予酒精处理后，下丘脑单胺能和肽能系统的功能受到干扰。与偏好水的大鼠不同，偏好酒精的大鼠下丘脑5-羟色胺水平较高，多巴胺和去甲肾上腺素水平较低，这与下丘脑去甲肾上腺素结构荧光强度的变化相关，并伴有室旁核区域九肽神经激素转运的显著紊乱。
