[Effects of acute and chronic alcohol poisoning on the noradrenaline content in the rat hypothalamus].

The content and distribution of norepinephrine in the hypothalamus following acute and chronic alcohol opisoning of animals (by introducing of a 20 degrees alcohol by mouth) was studied by applying biochemical and flurorscence histochemical methods. After poisoiing the content of neorpinephrine in the hypothalamus increased twice as compared with controls and continued to be high for 3 months. This was attended by a greater fluorescence intensity in the noradrenergic fibres, in the areas of the hypothalamic supra-optic nuclei and an inhibition of the transport and release of the neurosecretory material in the supra-optic neurohypophysial system was observed. And, conversely, 6--8 months after poisoning the content of neorpinephrine was halved in comparison with the controls.